Sigma-1 Receptor Agonist Amitriptyline Inhibits Store-Dependent Ca2+ Entry in Macrophages

被引：3
|
作者：
Krutetskaya, Z., I [1 ]
Milenina, L. S. [1 ]
Antonov, V. G. [1 ]
Nozdrachev, A. D. [1 ,2 ]
机构：
[1] St Petersburg State Univ, St Petersburg, Russia
[2] Russian Acad Sci, Inst Physiol, St Petersburg, Russia
来源：
DOKLADY BIOCHEMISTRY AND BIOPHYSICS | 2019年 / 488卷 / 01期
关键词：
PHARMACOLOGY;
D O I：
10.1134/S1607672919050041
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Using Fura-2AM microfluorimetry, we have shown for the first time that sigma-1 receptor agonist-tricyclic antidepressant amitriptyline-significantly inhibits store-dependent Ca2+ entry, induced by endoplasmic Ca2+-ATPase inhibitors thapsigargin and cyclopiazonic acid, in rat peritoneal macrophages. The results suggest a possible involvement of sigma-1 receptors in the regulation of store-dependent Ca2+ entry in macrophages.
引用
收藏
页码：307 / 310
页数：4
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