Dose-response effect of Red Maca (Lepidium meyenii) on benign prostatic hyperplasia induced by testosterone enanthate

被引:39
作者
Gasco, M. [1 ]
Villegas, L.
Yucra, S.
Rublo, J.
Gonzales, G. F.
机构
[1] Univ Peruana Cayetano Heredia, Dept Biol & Physiol Sci, Lima, Peru
[2] Univ Peruana Cayetano Heredia, Dept Pharmaceut Sci, Lima, Peru
[3] Univ Peruana Cayetano Heredia, Inst Invest Altura, Lima, Peru
[4] Univ Peruana Cayetano Heredia, Unit Qual Control Serv, Lima, Peru
关键词
Lepidium meyenii (Red Maca); glucosinolates; benign prostatic hyperplasia; rats;
D O I
10.1016/j.phymed.2006.12.003
中图分类号
Q94 [植物学];
学科分类号
071001 ;
摘要
The main goal of this study was to determine the effect of a freeze-dried aqueous extract of the red variety of Lepidium meyenii (Red Maca) on testosterone-induced benign prostatic hyperplasia (BPH) in adult rats of the Holtzman strain. Rats were treated with freeze-dried aqueous extract of Red Maca at doses of 0, 0.01, 0.05, 0.1, and 0.5 g/kg body wt. A positive control group received Finasteride (0.6 mg/kg body wt.). After treatment, the animals were sacrificed, and the ventral prostate was extracted, and weighed. HPLC was used to determine the presence of glucosinolates in Red Maca. The prostate Weight diminished in a dose-dependent fashion in rats treated with Red Maca. The effect of Red Maca was better than that observed with Finasteride. Finasteride, but not Red Maca, reduced seminal vesicles weight. Analysis of the HPLC indicated the presence of benzyl glucosinolate (Glucotropaeolin) with a content of 0.639%. Serum testosterone levels were not affected by Red Maca. Moreover, serum testosterone levels were not related to prostate or seminal vesicles weight in rats treated with vehicle and Red Maca. In conclusion, Red Maca administered orally in rats seems to exert an inhibitory effect at a level post DHT conversion, on the BPH-induced experimentally, although a direct measure of reductase action would still be required. (c) 2006 Elsevier GmbH. All rights reserved.
引用
收藏
页码:460 / 464
页数:5
相关论文
共 18 条
[1]   Lepidium meyenii (Maca) does not exert direct androgenic activities [J].
Bogani, P ;
Simonini, F ;
Iriti, M ;
Rossoni, M ;
Faoro, F ;
Poletti, A ;
Visioli, F .
JOURNAL OF ETHNOPHARMACOLOGY, 2006, 104 (03) :415-417
[2]   Effect of an integral suspension of Lepidium latifolium on prostate hyperplasia in rats [J].
Caballero, SM ;
Fernández, CC ;
Pérez-Fernández, R .
FITOTERAPIA, 2004, 75 (02) :187-191
[3]   Ingestion of an isothiocyanate metabolite from cruciferous vegetables inhibits growth of human prostate cancer cell xenografts by apoptosis and cell cycle arrest [J].
Chiao, JW ;
Wu, HY ;
Ramaswamy, G ;
Conaway, CC ;
Chung, FL ;
Wang, LG ;
Liu, DL .
CARCINOGENESIS, 2004, 25 (08) :1403-1408
[4]   The chemical diversity and distribution of glucosinolates and isothiocyanates among plants [J].
Fahey, JW ;
Zalcmann, AT ;
Talalay, P .
PHYTOCHEMISTRY, 2001, 56 (01) :5-51
[5]   Comparison of the pharmacological effects of a novel selective androgen receptor modulator, the 5α-reductase inhibitor finasteride, and the antiandrogen hydroxyflutamide in intact rats:: New approach for benign prostate hyperplasia [J].
Gao, WQ ;
Kearbey, JD ;
Nair, VA ;
Chung, KW ;
Parlow, AF ;
Miller, DD ;
Dalton, JT .
ENDOCRINOLOGY, 2004, 145 (12) :5420-5428
[6]   Red maca (Lepidium meyenii) reduced prostate size in rats -: art. no. 5 [J].
Gonzales, GF ;
Miranda, S ;
Nieto, J ;
Fernández, G ;
Yucra, S ;
Rubio, J ;
Yi, P ;
Gasco, M .
REPRODUCTIVE BIOLOGY AND ENDOCRINOLOGY, 2005, 3 (1)
[7]   Changes in testosterone and dihydrotestosterone levels in male rat accessory sex organs, serum, and seminal fluid after castration: Establishment of a new highly sensitive simultaneous androgen measurement method [J].
Kashiwagi, B ;
Shibata, Y ;
Ono, Y ;
Suzuki, R ;
Honma, S ;
Suzuki, K .
JOURNAL OF ANDROLOGY, 2005, 26 (05) :586-591
[8]   Brassica vegetables and prostate cancer risk:: A review of the epidemiological evidence [J].
Kristal, AR ;
Lampe, JW .
NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL, 2002, 42 (01) :1-9
[9]   Plant-derived 3,3′-diindolylmethane is a strong androgen antagonist in human prostate cancer cells [J].
Le, HT ;
Schaldach, CM ;
Firestone, GL ;
Bjeldanes, LF .
JOURNAL OF BIOLOGICAL CHEMISTRY, 2003, 278 (23) :21136-21145
[10]   Reduction of rat prostate weight by combined quercetin-finasteride treatment is associated with cell cycle deregulation [J].
Ma, ZS ;
Nguyen, TH ;
Huynh, TH ;
Do, PT ;
Huynh, H .
JOURNAL OF ENDOCRINOLOGY, 2004, 181 (03) :493-507