Extracellular vesicle activities regulating macrophage- and tissue-mediated injury and repair responses

被引:196
作者
Hu, Qian [1 ]
Lyon, Christopher J. [2 ,3 ]
Fletcher, Jesse K. [2 ,3 ]
Tang, Wenfu [1 ]
Wan, Meihua [1 ]
Hu, Tony Y. [2 ,3 ]
机构
[1] Sichuan Univ, West China Hosp, Dept Integrated Tradit Chinese & Western Med, Chengdu 610041, Peoples R China
[2] Tulane Univ, Ctr Cellular & Mol Diag, Sch Med, New Orleans, LA 70112 USA
[3] Tulane Univ, Dept Biochem & Mol Biol, Sch Med, New Orleans, LA 70112 USA
关键词
Extracellular vesicles; Macrophage; Tissue injury; Inflammatory disease; Interaction loop; Stem cell; Sepsis; Targeted therapy; MESENCHYMAL STEM-CELLS; SEVERE ACUTE-PANCREATITIS; INDUCED INFLAMMATION; ULCERATIVE-COLITIS; LUNG INFLAMMATION; EPITHELIAL-CELLS; M2; POLARIZATION; CARBON-MONOXIDE; LIVER-INJURY; IN-VITRO;
D O I
10.1016/j.apsb.2020.12.014
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
Macrophages are typically identified as classically activated (M1) macrophages and alternatively activated (M2) macrophages, which respectively exhibit pro- and anti-inflammatory phenotypes, and the balance between these two subtypes plays a critical role in the regulation of tissue inflammation, injury, and repair processes. Recent studies indicate that tissue cells and macrophages interact via the release of small extracellular vesicles ( EVs) in processes where EVs released by stressed tissue cells can promote the activation and polarization of adjacent macrophages which can in turn release EVs and factors that can promote cell stress and tissue inflammation and injury, and vice versa. This review discusses the roles of such EVs in regulating such interactions to influence tissue inflammation and injury in a number of acute and chronic inflammatory disease conditions, and the potential applications, advantage and concerns for using EV-based therapeutic approaches to treat such conditions, including their potential role of drug carriers for the treatment of infectious diseases. (C) 2021 Chinese Pharmaceutical Association and Institute of Materia Medica, Chinese Academy of Medical Sciences. Production and hosting by Elsevier B.V.
引用
收藏
页码:1493 / 1512
页数:20
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