Complement 5a Receptor Polymorphisms Are Associated With Panton-Valentine Leukocidin-positive Staphylococcus aureus Colonization in African Pygmies

被引：5
|
作者：
Schaumburg, Frieder [1 ]
Witten, Anika [2 ]
Flamen, Arnaud [3 ]
Stoll, Monika [2 ]
Alabi, Abraham S. [4 ,5 ]
Kremsner, Peter G. [4 ,5 ]
Loeffler, Bettina [6 ]
Zipfel, Peter F. [7 ]
Velavan, Thirumalaisamy P. [5 ,8 ,9 ]
Peters, Georg [1 ]
机构：
[1] Univ Hosp Munster, Inst Med Microbiol, Domagkstr 10, D-48149 Munster, Germany
[2] Univ Munster, Core Facil Genom, Munster, Germany
[3] Hop Albert Schweitzer, Deschapelles, Artibonite, Haiti
[4] Ctr Rech Med Lambarene CERMEL, Lambarene, Gabon
[5] Eberhard Karls Univ Tubingen, Inst Tropenmed, Deutsch Zentrum Infekt Forsch, Tubingen, Germany
[6] Univ Hosp Jena, Inst Med Microbiol, Jena, Germany
[7] Hans Knoell Inst, Leibniz Inst Nat Prod Res & Infect Biol, Jena, Germany
[8] Vietnamese German Ctr Med Res, Hanoi, Vietnam
[9] DuyTan Univ, Fac Med, Da Nang, Vietnam
来源：
CLINICAL INFECTIOUS DISEASES | 2019年 / 68卷 / 05期
关键词：
Staphylococcus aureus; complement C5a; receptor; Panton-Valentine leukocidin; polymorphism; EPIDEMIOLOGY;
D O I：
10.1093/cid/ciy666
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Panton-Valentine leukocidin (PVL) is common in African Staphylococcus aureus and can be associated with skin and soft tissue infection. PVL-positive S. aureus colonization is associated with a variant of complement receptor 5a, the cellular target of the lukS PVL subunit.
引用
收藏
页码：854 / 856
页数：3
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