Correlates of Protection for M Protein-Based Vaccines against Group A Streptococcus

被引：27
|
作者：
Tsoi, Shu Ki [1 ]
Smeesters, Pierre R. [1 ,2 ]
Frost, Hannah R. C. [1 ]
Licciardi, Paul [3 ,4 ]
Steer, Andrew C. [1 ,2 ,4 ]
机构：
[1] Murdoch Childrens Res Inst, Grp A Streptococcus Res Grp, Melbourne, Vic 3052, Australia
[2] Univ Melbourne, Ctr Int Child Hlth, Melbourne, Vic 3052, Australia
[3] Murdoch Childrens Res Inst, Pneumococcal Res Grp, Melbourne, Vic 3052, Australia
[4] Royal Childrens Hosp, Dept Paediat, Melbourne, Vic 3052, Australia
来源：
JOURNAL OF IMMUNOLOGY RESEARCH | 2015年 / 2015卷
关键词：
PNEUMOCOCCAL CONJUGATE VACCINE; CLUSTER TYPING SYSTEM; OPSONOPHAGOCYTOSIS ASSAY; INTRANASAL IMMUNIZATION; FUNCTIONAL ANTIBODIES; MATERNAL ANTIBODY; CONSERVED REGION; T-CELL; CHALLENGE; EFFICACY;
D O I：
10.1155/2015/167089
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Group A streptococcus (GAS) is known to cause a broad spectrum of illness, from pharyngitis and impetigo, to autoimmune sequelae such as rheumatic heart disease, and invasive diseases. It is a significant cause of infectious disease morbidity and mortality worldwide, but no efficacious vaccine is currently available. Progress in GAS vaccine development has been hindered by a number of obstacles, including a lack of standardization in immunoassays and the need to define human correlates of protection. In this review, we have examined the current immunoassays used in both GAS and other organisms, and explored the various challenges in their implementation in order to propose potential future directions to identify a correlate of protection and facilitate the development of M protein-based vaccines, which are currently the main GAS vaccine candidates.
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页数：11
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