Synthesis of 4-Quinolones through Nickel-Catalyzed Intramolecular Amination on the β-Carbon of o-(N-Alkylamino)propiophenones

被引：15

作者：

Ueno, Satoshi ^{[1
]}

Shimizu, Ryosuke ^{[1
]}

Maeda, Ryohei ^{[1
]}

Kuwano, Ryoichi ^{[1
]}

机构：

[1] Kyushu Univ, Grad Sch Sci, Dept Chem, Higashi Ku, Fukuoka 8128581, Japan

来源：

SYNLETT | 2012年 / 11期

关键词：

nickel; cyclization; amination; ketones; oxidation; SUGASAWA REACTION; 2-ARYL-4-QUINOLONES; 4-HYDROXYQUINOLINE; CYCLIZATION; AMIDATION; INHIBITOR; ANILINES; MILD;

D O I：

10.1055/s-0031-1291146

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

o-(N-Alkylamino)propiophenones are converted into 4-quinolones in the presence of chlorobenzene, potassium phosphate, morpholine, and nickel(0) catalyst. The reaction proceeds through the nickel-catalyzed formation of beta-enaminones from o-(N-alkylamino)propiophenones and morpholine, followed by the intramolecular transamination.

引用

页码：1639 / 1642

页数：4

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