Peptide-induced RAFT polymerization via an amyloid-β17-20-based chain transfer agent

被引：9

作者：

Kumar, Sonu ^{[1
,2
]}

Binder, Wolfgang H. ^{[1
]}

机构：

[1] Martin Luther Univ Halle Wittenberg, Fac Nat Sci Chem Phys & Math 2, Inst Chem, Macromol Chem, Von Danckelmann Pl 4, D-06120 Halle, Saale, Germany

[2] Punjab Engn Coll Deemed Be Univ, Dept Appl Sci Chem, Sect 12, Chandigarh 160012, India

来源：

SOFT MATTER | 2020年 / 16卷 / 30期

关键词：

AMYLOID-BETA-PEPTIDE; LIVING RADICAL POLYMERIZATION; REVERSIBLE ADDITION; SYNTHETIC STRATEGIES; HYDROGELS; ALZHEIMERS; POLYMERS; GLYCOL); ACID; THERAPEUTICS;

D O I：

10.1039/d0sm01169j

中图分类号：

O64 [物理化学（理论化学）、化学物理学];

学科分类号：

070304 ; 081704 ;

摘要：

We here describe the synthesis of a novel peptide/polymer-conjugate, embedding the amyloid-beta (A beta) protein core sequence Leu-Val-Phe-Phe (LVFF, A beta(17-20))viaRAFT polymerization. Based on a novel chain transfer-agent, the "grafting-from" approach effectively generates the well-defined peptide-polymer conjugates with appreciably high monomer conversion rate, resulting in mechanically stiffer peptide-functional cross-linked polymeric hydrogels.

引用

页码：6964 / 6968

页数：5

共 72 条

[41] A17-20 Peptide-Guided Structuring of Polymeric Conjugates and Their pH-Triggered Dynamic Response
Kumar, Sonu
Bheemireddy, Varun
De, Priyadarsi
[J]. MACROMOLECULAR BIOSCIENCE, 2015, 15 (10) : 1447 - 1456
[42] Fluorescent labelled dual-stimuli (pH/thermo) responsive self-assembled side-chain amino acid based polymers
Kumar, Sonu
De, Priyadarsi
[J]. POLYMER, 2014, 55 (03) : 824 - 832
[43] Thio-Bromo "Click" Reaction Derived Polymer-Peptide Conjugates for Their Self-Assembled Fibrillar Nanostructures
Kumar, Sonu
Hause, Gerd
Binder, Wolfgang H.
[J]. MACROMOLECULAR BIOSCIENCE, 2020, 20 (06)
[44] Functional polymers from novel carboxyl-terminated trithiocarbonates as highly efficient RAFT agents
Lai, JT
Filla, D
Shea, R
[J]. MACROMOLECULES, 2002, 35 (18) : 6754 - 6756
[45] Cyclic Peptide-Polymer Conjugates: Grafting-to vs Grafting-From
Larnaudie, Sophie C.
Brendel, Johannes C.
Jolliffe, Katrina A.
Perrier, Sebastien
[J]. JOURNAL OF POLYMER SCIENCE PART A-POLYMER CHEMISTRY, 2016, 54 (07) : 1003 - 1011
[46] Recent advances in the design of bioconjugates from controlled/living radical polymerization
Le Droumaguet, Benjamin
Nicolas, Julien
[J]. POLYMER CHEMISTRY, 2010, 1 (05) : 563 - 598
[47] 50th Anniversary Perspective: Polymeric Biomaterials: Diverse Functions Enabled by Advances in Macromolecular Chemistry
Liang, Yingkai
Li, Linqing
Scott, Rebecca A.
Kiick, Kristi L.
[J]. MACROMOLECULES, 2017, 50 (02) : 483 - 502
[48] Antimicrobial polylysine decorated nanostructures prepared through polymerization induced self-assembly (PISA)
Luppi, L.
Babut, T.
Petit, E.
Rolland, M.
Quemener, D.
Soussan, L.
Moradi, M. A.
Semsarilar, M.
[J]. POLYMER CHEMISTRY, 2019, 10 (03) : 336 - 344
[49] Polymerization of oligo(ethylene glycol) (meth)acrylates: Toward new generations of smart biocompatible materials
Lutz, Jean-Francois
[J]. JOURNAL OF POLYMER SCIENCE PART A-POLYMER CHEMISTRY, 2008, 46 (11) : 3459 - 3470
[50] Thermo-Switchable Materials Prepared Using the OEGMA-Platform
Lutz, Jean-Francois
[J]. ADVANCED MATERIALS, 2011, 23 (19) : 2237 - 2243

← 1 2 3 4 5 6 7 8 →