Peptide-induced RAFT polymerization via an amyloid-β17-20-based chain transfer agent

被引：9

作者：

Kumar, Sonu ^{[1
,2
]}

Binder, Wolfgang H. ^{[1
]}

机构：

[1] Martin Luther Univ Halle Wittenberg, Fac Nat Sci Chem Phys & Math 2, Inst Chem, Macromol Chem, Von Danckelmann Pl 4, D-06120 Halle, Saale, Germany

[2] Punjab Engn Coll Deemed Be Univ, Dept Appl Sci Chem, Sect 12, Chandigarh 160012, India

来源：

SOFT MATTER | 2020年 / 16卷 / 30期

关键词：

AMYLOID-BETA-PEPTIDE; LIVING RADICAL POLYMERIZATION; REVERSIBLE ADDITION; SYNTHETIC STRATEGIES; HYDROGELS; ALZHEIMERS; POLYMERS; GLYCOL); ACID; THERAPEUTICS;

D O I：

10.1039/d0sm01169j

中图分类号：

O64 [物理化学（理论化学）、化学物理学];

学科分类号：

070304 ; 081704 ;

摘要：

We here describe the synthesis of a novel peptide/polymer-conjugate, embedding the amyloid-beta (A beta) protein core sequence Leu-Val-Phe-Phe (LVFF, A beta(17-20))viaRAFT polymerization. Based on a novel chain transfer-agent, the "grafting-from" approach effectively generates the well-defined peptide-polymer conjugates with appreciably high monomer conversion rate, resulting in mechanically stiffer peptide-functional cross-linked polymeric hydrogels.

引用

页码：6964 / 6968

页数：5

共 72 条

[1] Small-Peptide-Based Organogel Kit: Towards the Development of Multicomponent Self-Sorting Organogels
Afrasiabi, Rouzbeh
Kraatz, Heinz-Bernhard
[J]. CHEMISTRY-A EUROPEAN JOURNAL, 2013, 19 (47) : 15862 - 15871
[2] Self-assembly of fibers and fibrils
Binder, Wolfgang H.
Smrzka, Oskar W.
[J]. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2006, 45 (44) : 7324 - 7328
[3] Amphiphilic block copolymers in drug delivery: advances in formulation structure and performance
Bodratti, Andrew M.
Alexandridis, Paschalis
[J]. EXPERT OPINION ON DRUG DELIVERY, 2018, 15 (11) : 1085 - 1104
[4] Hydrogels for Therapeutic Delivery: Current Developments and Future Directions
Buwalda, Sytze J.
Vermonden, Tina
Hennink, Wim E.
[J]. BIOMACROMOLECULES, 2017, 18 (02) : 316 - 330
[5] Polypeptide-polymer bioconjugates
Canalle, Luiz A.
Lowik, Dennis W. P. M.
van Hest, Jan C. M.
[J]. CHEMICAL SOCIETY REVIEWS, 2010, 39 (01) : 329 - 353
[6] Supramolecular Hydrogel Formation in a Series of Self-Assembling Lipopeptides with Varying Lipid Chain Length
Castelletto, V.
Kaur, A.
Kowalczyk, R. M.
Hamley, I. W.
Reza, M.
Ruokolainen, J.
[J]. BIOMACROMOLECULES, 2017, 18 (07) : 2013 - 2023
[7] Self-Assembly and Anti-Amyloid Cytotoxicity Activity of Amyloid beta Peptide Derivatives
Castelletto, V.
Ryumin, P.
Cramer, R.
Hamley, I. W.
Taylor, M.
Allsop, D.
Reza, M.
Ruokolainen, J.
Arnold, T.
Hermida-Merino, D.
Garcia, C. I.
Leal, M. C.
Castano, E.
[J]. SCIENTIFIC REPORTS, 2017, 7
[8] Tunable Length of Cyclic Peptide-Polymer Conjugate Self Assemblies in Water
Catrouillet, Sylvain
Brendel, Johannes C.
Larnaudie, Sophie
Barlow, Tammie
Jolliffe, Katrina A.
Perrier, Sebastien
[J]. ACS MACRO LETTERS, 2016, 5 (10) : 1119 - 1123
[9] Recent trends in pH/thermo-responsive self-assembling hydrogels: from polyions to peptide-based polymeric gelators
Chassenieux, Christophe
Tsitsilianis, Constantinos
[J]. SOFT MATTER, 2016, 12 (05) : 1344 - 1359
[10] Cell-Penetrating, Peptide-Based RAFT Agent for Constructing Penetration Enhancers
Chen, Chao
Richter, Friederike
Guerrero-Sanchez, Carlos
Traeger, Anja
Schubert, Ulrich S.
Feng, Anchao
Thang, San H.
[J]. ACS MACRO LETTERS, 2020, 9 (02) : 260 - 265

← 1 2 3 4 5 6 7 8 →