Palladium-Catalyzed Oxidative Carbonylation of Benzylic C-H Bonds via Nondirected C(sp3)-H Activation

被引：246

作者：

Xie, Pan ^{[1
]}

Xie, Yinjun ^{[1
]}

Qian, Bo ^{[1
]}

Zhou, Han ^{[1
]}

Xia, Chungu ^{[1
]}

Huang, Hanmin ^{[1
]}

机构：

[1] Chinese Acad Sci, Lanzhou Inst Chem Phys, State Key Lab Oxo Synth & Select Oxidat, Lanzhou 730000, Peoples R China

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2012年 / 134卷 / 24期

基金：

中国国家自然科学基金;

关键词：

CARBON-HYDROGEN BONDS; PHENYLACETIC ACIDS; AROMATIC-COMPOUNDS; COUPLING REACTIONS; ARYL; CARBOXYLATION; AMINATION; MONOXIDE; HALIDES; HYDROCARBONS;

D O I：

10.1021/ja3036459

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A new strategy for generating benzylpalladium reactive species from toluenes via nondirected C(sp(3))-H activation has been developed. This led to construction of an efficient Pd-catalyzed reaction protocol for the oxidative carboxylation of benzylic C-H bonds to form substituted 2-phenylacetic acid esters and derivatives from inexpensive, commercially available starting materials.

引用

页码：9902 / 9905

页数：4

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