Base-promoted direct synthesis of functionalized N-arylindoles via the cascade reactions of allenic ketones with indoles

被引：12

作者：

Li, Shengxiao ^{[1
]}

Wu, Xin-Xing ^{[1
]}

Chen, Shufeng ^{[1
]}

机构：

[1] Inner Mongolia Univ, Dept Chem & Chem Engn, Inner Mongolia Key Lab Fine Organ Synth, Hohhot 010021, Peoples R China

来源：

ORGANIC & BIOMOLECULAR CHEMISTRY | 2019年 / 17卷 / 04期

基金：

中国国家自然科学基金;

关键词：

ARYL BOND FORMATION; 1,2-ALLENIC KETONES; CHEMISTRY; FERROCENYLALLENE; CYCLOADDITIONS; ACTIVATION; BENZENES; ALKENES; ACIDS;

D O I：

10.1039/c8ob02921k

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A convenient Cs2CO3-promoted cascade benzannulation reaction of allenic ketones with indoles was achieved for the synthesis of functionalized N-arylindole derivatives under transition-metal-free conditions. A series of readily available starting materials can undergo the process successfully. It represents a practical method for the construction of N-arylindole scaffolds with high atom economy.

引用

页码：789 / 793

页数：5

共 3 条

[1] Synthesis of Functionalized Phenols via the Cascade Reactions of Allenic Ketones with β-Diketones
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[3] Synthesis of ester-functionalized indolo[2,1-a]isoquinolines via iron-catalyzed radical cascade cyclization of 2-aryl-N-acryloyl indoles with carbazates
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ORGANIC & BIOMOLECULAR CHEMISTRY, 2022, 20 (29) : 5704 - 5711

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