Lewis acid catalyzed C-3 alkylidenecyclopentenylation of indoles: an easy access to functionalized indoles and bisindoles

被引：7
作者：
Chand, S. Sarath [1 ,2 ]
Sasidhar, B. S. [1 ,2 ]
Prakash, Praveen [2 ]
Sasikumar, P. [2 ]
Preethanuj, P. [2 ]
Jaroschik, Florian [3 ]
Harakat, Dominique [3 ]
Vasse, Jean-Luc [3 ]
Radhakrishnan, K. V. [1 ,2 ]
机构：
[1] Acad Sci & Innovat Res AcSIR, New Delhi 110001, India
[2] CSIR, Organ Chem Sect, Natl Inst Interdisciplinary Sci & Technol, Trivandrum 695019, Kerala, India
[3] Univ Reims, F-51687 Reims 2, France
来源：
RSC ADVANCES | 2015年 / 5卷 / 48期
关键词：
ONE-POT STRATEGY; FRIEDEL-CRAFTS ALKYLATIONS; MESO BICYCLIC HYDRAZINES; STEREOSELECTIVE-SYNTHESIS; DIAZABICYCLIC ALKENES; FACILE ROUTE; ARYL IODIDES; OLEFINS; PENTAFULVENES; CYCLOADDITION;
D O I：
10.1039/c5ra01107h
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
A Lewis acid catalyzed C-3 alkylidenecylopentenylation of indoles through the ring opening of pentafulvene derived diazabicyclic olefins has been developed. The present protocol offers an efficient route toward the synthesis of indole and bisindole derivatives. The role of the hydrazine group, as a reaction carrier in the strategy has also been demonstrated by the stepwise synthesis of functionalized bisindole.
引用
收藏
页码：38075 / 38084
页数：10
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