Plasma concentrations of asymmetric dimethylarginine are increased in patients with type 2 diabetes mellitus

被引：312
作者：
Abbasi, F [1 ]
Asagmi, T [1 ]
Cooke, JP [1 ]
Lamendola, C [1 ]
McLaughlin, T [1 ]
Reaven, GM [1 ]
Stuehlinger, M [1 ]
Tsao, PS [1 ]
机构：
[1] Stanford Univ, Med Ctr, Sch Med, Falk CVRC,Div Cardiovasc Med, Stanford, CA 94305 USA
来源：
AMERICAN JOURNAL OF CARDIOLOGY | 2001年 / 88卷 / 10期
关键词：
D O I：
10.1016/S0002-9149(01)02063-X
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Increased risk of coronary heart disease in patients with type 2 diabetes cannot be accounted for by differences in conventional risk factors. This study demonstrates that plasma concentrations of asymmetric dimethylarginine, an endogenous inhibitor of nitric oxide synthase, are increased in patients with type 2 diabetes, thereby identifying a new and potentially important coronary heart disease risk factor in this patient population.
引用
收藏
页码：1201 / +
页数：4
相关论文
共 19 条
  • [1] American Diabetes Association, 1998, DIABETES CARE S1, V21, ps5
  • [2] Forearm nitric oxide balance, vascular relaxation, and glucose metabolism in NIDDM patients
    Avogaro, A
    Piarulli, F
    Valerio, A
    Miola, M
    Calveri, M
    Pavan, P
    Vicini, P
    Cobelli, C
    Tiengo, A
    Calo, L
    DelPrato, S
    [J]. DIABETES, 1997, 46 (06) : 1040 - 1046
  • [3] Elevated L-arginine/dimethylarginine ratio contributes to enhanced systemic NO production by dietary L-arginine in hypercholesterolemic rabbits
    BodeBoger, SM
    Boger, RH
    Kienke, S
    Junker, W
    Frolich, JC
    [J]. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 1996, 219 (02) : 598 - 603
  • [4] Asymmetric dimethylarginine (ADMA):: A novel risk factor for endothelial dysfunction -: Its role in hypercholesterolemia
    Böger, RH
    Bode-Böger, SM
    Szuba, A
    Tsao, PS
    Chan, JR
    Tangphao, O
    Blaschke, TF
    Cooke, JP
    [J]. CIRCULATION, 1998, 98 (18) : 1842 - 1847
  • [5] CHRONIC INHIBITION OF NITRIC-OXIDE PRODUCTION ACCELERATES NEOINTIMA FORMATION AND IMPAIRS ENDOTHELIAL FUNCTION IN HYPERCHOLESTEROLEMIC RABBITS
    CAYATTE, AJ
    PALACINO, JJ
    HORTEN, K
    COHEN, RA
    [J]. ARTERIOSCLEROSIS AND THROMBOSIS, 1994, 14 (05): : 753 - 759
  • [6] Does ADMA cause endothelial dysfunction?
    Cooke, JP
    [J]. ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, 2000, 20 (09) : 2032 - 2037
  • [7] Cardiovascular disease in diabetes mellitus type 2: a potential role for novel cardiovascular risk factors
    Hayden, JM
    Reaven, PD
    [J]. CURRENT OPINION IN LIPIDOLOGY, 2000, 11 (05) : 519 - 528
  • [8] Disruption of the endothelial nitric oxide synthase gene: Effect on vascular response to injury
    Huang, PL
    [J]. AMERICAN JOURNAL OF CARDIOLOGY, 1998, 82 (10A) : 57S - 58S
  • [9] Novel mechanism for endothelial dysfunction - Dysregulation of dimethylarginine dimethylaminohydrolase
    Ito, A
    Tsao, PS
    Adimoolam, S
    Kimoto, M
    Ogawa, T
    Cooke, JP
    [J]. CIRCULATION, 1999, 99 (24) : 3092 - 3095
  • [10] Accelerated intimal hyperplasia and increased endogenous inhibitors for NO synthesis in rabbits with alloxan-induced hyperglycaemia
    Masuda, H
    Goto, M
    Tamaoki, S
    Azuma, H
    [J]. BRITISH JOURNAL OF PHARMACOLOGY, 1999, 126 (01) : 211 - 218
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