Plasma concentrations of asymmetric dimethylarginine are increased in patients with type 2 diabetes mellitus

被引：316

作者：

Abbasi, F ^{[1
]}

Asagmi, T ^{[1
]}

Cooke, JP ^{[1
]}

Lamendola, C ^{[1
]}

McLaughlin, T ^{[1
]}

Reaven, GM ^{[1
]}

Stuehlinger, M ^{[1
]}

Tsao, PS ^{[1
]}

机构：

[1] Stanford Univ, Med Ctr, Sch Med, Falk CVRC,Div Cardiovasc Med, Stanford, CA 94305 USA

来源：

AMERICAN JOURNAL OF CARDIOLOGY | 2001年 / 88卷 / 10期

关键词：

D O I：

10.1016/S0002-9149(01)02063-X

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Increased risk of coronary heart disease in patients with type 2 diabetes cannot be accounted for by differences in conventional risk factors. This study demonstrates that plasma concentrations of asymmetric dimethylarginine, an endogenous inhibitor of nitric oxide synthase, are increased in patients with type 2 diabetes, thereby identifying a new and potentially important coronary heart disease risk factor in this patient population.

引用

页码：1201 / +

页数：4

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