Pilot Study: Alteration of Deleted in Liver Cancer1 and Phosphorylated Focal Adhesion Kinase Y397 Cytoplasmic Expression and the Prognostic Value in Advanced Epithelial Ovarian Carcinoma

被引：8
作者：
Fan, Dong-Mei [1 ,2 ]
Shi, Hui-Rong [1 ]
机构：
[1] Zhengzhou Univ, Dept Obstet & Gynecol, Affiliated Hosp 1, Zhengzhou 450052, Peoples R China
[2] Henan Univ Sci & Technol, Affiliated Hosp 1, Dept Gynecol, Luoyang 471003, Peoples R China
来源：
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2011年 / 12卷 / 12期
关键词：
DLC1; gynecologic cancers; ovarian carcinoma; prognosis; p-FAK; TUMOR-SUPPRESSOR GENE; GTPASE-ACTIVATING PROTEIN; HEPATOCELLULAR-CARCINOMA; CELL-PROLIFERATION; DLC-1; INVASION; RHO; MIGRATION; SURVIVAL; GROWTH;
D O I：
10.3390/ijms12128489
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Background: Deletion in liver cancer gene (DLC1) and phosphorylated focal adhesion kinase (p-FAK) have recently been reported as metastasis-related genes. However, the roles and prognostic values of their expression in epithelial ovarian carcinomas (EOCs) remain unclear. Methods: The expression and prognostic value of DLC1 and p-FAK Y397 in EOC were evaluated by immunohistochemistry and multivariate analysis. Results: Low expression of DLC1 and high expression of p-FAK Y397 were found in the 76 cases of EOC. The expression of DLC1 and p-FAK Y397 were negatively correlated. Multivariate analysis showed that the combination of them was an independent prognostic marker of EOC (P = 0.0319). Conclusions: DLC1 and pFAK Y397 had an association with the clinicopathologic characteristics of EOC. Expression of neither of these genes was a prognostic factor alone, but the combination revealed a significant prognostic value in the 60 cases of advanced stage EOC.
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收藏
页码：8489 / 8501
页数：13
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