A three-component coupling protocol for the synthesis of substituted hexahydropyrrolo[3,2-c]quinolines

被引：120

作者：

Batey, RA ^{[1
]}

Simoncic, PD ^{[1
]}

Lin, D ^{[1
]}

Smyj, RP ^{[1
]}

Lough, AJ ^{[1
]}

机构：

[1] Univ Toronto, Dept Chem, Toronto, ON M5S 3H6, Canada

来源：

CHEMICAL COMMUNICATIONS | 1999年 / 07期

关键词：

D O I：

10.1039/a809614g

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

One pot reaction of anilines, benzaldehydes and 2-pyrrolines under lanthanide triflate catalysis affords substituted hexahydropyrrolo[3,2-c]quinolines in good to excellent yields.

引用

页码：651 / 652

页数：2

共 25 条

[1]

[Anonymous], 1991, Comprehensive Organic Synthesis

[2] Multiple-component condensation strategies for combinatorial library synthesis [J].

Armstrong, RW ;

Combs, AP ;

Tempest, PA ;

Brown, SD ;

Keating, TA .

ACCOUNTS OF CHEMICAL RESEARCH, 1996, 29 (03) :123-131

[3] REVERSIBLE INHIBITORS OF THE GASTRIC (H+/K+)-ATPASE .1. 1-ARYL-4-METHYLPYRROLO[3,2-C]QUINOLINES AS CONFORMATIONALLY RESTRAINED ANALOGS OF 4-(ARYLAMINO)QUINOLINES [J].

BROWN, TH ;

IFE, RJ ;

KEELING, DJ ;

LAING, SM ;

LEACH, CA ;

PARSONS, ME ;

PRICE, CA ;

REAVILL, DR ;

WIGGALL, KJ .

JOURNAL OF MEDICINAL CHEMISTRY, 1990, 33 (02) :527-533

[4]

Gurjar MK, 1997, HETEROCYCLES, V45, P231

[5] Bradykinin receptors [J].

Hall, JM .

GENERAL PHARMACOLOGY, 1997, 28 (01) :1-6

[6] A synthesis of the tricyclic pyrroloquinoline core of martinelline [J].

Ho, TCT ;

Jones, K .

TETRAHEDRON, 1997, 53 (24) :8287-8294

[7]

Imamoto T., 1994, LANTHANIDES ORGANIC

[8] SYNTHESIS OF 4-HETEROCYCLYL-HEXAHYDRO-8-METHOXYFURO[3,2-C]QUINOLINES BY LEWIS ACID-CATALYZED [4+2]CYCLOADDITION REACTION [J].

KAMETANI, T ;

FURUYAMA, H ;

FUKUOKA, Y ;

TAKEDA, H ;

SUZUKI, Y ;

HONDA, T .

JOURNAL OF HETEROCYCLIC CHEMISTRY, 1986, 23 (01) :185-187

[9] SYNTHESIS OF QUINOLINE DERIVATIVES BY [4+2]CYCLOADDITION REACTION [J].

KAMETANI, T ;

TAKEDA, H ;

SUZUKI, Y ;

HONDA, T .

SYNTHETIC COMMUNICATIONS, 1985, 15 (06) :499-505

[10] Recent progress in the synthesis of 1,2,3,4-tetrahydroquinolines [J].

Katritzky, AR ;

Rachwal, S ;

Rachwal, B .

TETRAHEDRON, 1996, 52 (48) :15031-15070

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