Effect of Oxaliplatin on Voltage-Gated Sodium Channels in Peripheral Neuropathic Pain

被引:7
作者
Kim, Woojin [1 ]
机构
[1] Kyung Hee Univ, Dept Physiol, Coll Korean Med, Seoul 02453, South Korea
关键词
allodynia; oxaliplatin; peripheral neuropathic pain; voltage-gated sodium channel; INDUCED NEUROTOXICITY; ANTICANCER AGENT; PREVENTION; NA+; EXPRESSION; DULOXETINE; POTENTIALS; MECHANISMS; MANAGEMENT; JUNCTIONS;
D O I
10.3390/pr8060680
中图分类号
TQ [化学工业];
学科分类号
0817 ;
摘要
Oxaliplatin is a chemotherapeutic drug widely used to treat various types of tumors. However, it can induce a serious peripheral neuropathy characterized by cold and mechanical allodynia that can even disrupt the treatment schedule. Since the approval of the agent, many laboratories, including ours, have focused their research on finding a drug or method to decrease this side effect. However, to date no drug that can effectively reduce the pain without causing any adverse events has been developed, and the mechanism of the action of oxaliplatin is not clearly understood. On the dorsal root ganglia (DRG) sensory neurons, oxaliplatin is reported to modify their functions, such as the propagation of the action potential and induction of neuropathic pain. Voltage-gated sodium channels in the DRG neurons are important, as they play a major role in the excitability of the cell by initiating the action potential. Thus, in this small review, eight studies that investigated the effect of oxaliplatin on sodium channels of peripheral neurons have been included. Its effects on the duration of the action potential, peak of the sodium current, voltage-response relationship, inactivation current, and sensitivity to tetrodotoxin (TTX) are discussed.
引用
收藏
页数:13
相关论文
共 57 条
  • [1] The chemotherapeutic oxaliplatin alters voltage-gated Na+ channel kinetics on rat sensory neurons
    Adelsberger, H
    Quasthoff, S
    Grosskreutz, J
    Lepier, A
    Eckel, F
    Lersch, C
    [J]. EUROPEAN JOURNAL OF PHARMACOLOGY, 2000, 406 (01) : 25 - 32
  • [2] Topiramate prevents oxaliplatin-related axonal hyperexcitability and oxaliplatin induced peripheral neurotoxicity
    Alberti, Paola
    Canta, Annalisa
    Chiorazzi, Alessia
    Fumagalli, Giulia
    Meregalli, Cristina
    Monza, Laura
    Pozzi, Eleonora
    Ballarini, Elisa
    Rodriguez-Menendez, Virginia
    Oggioni, Norberto
    Sancini, Giulio
    Marmiroli, Paola
    Cavaletti, Guido
    [J]. NEUROPHARMACOLOGY, 2020, 164
  • [3] A review on oxaliplatin-induced peripheral nerve damage
    Argyriou, Andreas A.
    Polychronopoulos, Panagiotis
    Iconomou, Gregoris
    Chroni, Elisabeth
    Kalofonos, Haralabos P.
    [J]. CANCER TREATMENT REVIEWS, 2008, 34 (04) : 368 - 377
  • [4] THE ROLE OF VOLTAGE-GATED SODIUM CHANNELS IN PAIN SIGNALING
    Bennett, David L.
    Clark, Alex J.
    Huang, Jianying
    Waxman, Stephen G.
    Dib-Hajj, Sulayman D.
    [J]. PHYSIOLOGICAL REVIEWS, 2019, 99 (02) : 1079 - 1151
  • [5] Benoit E, 2006, GEN PHYSIOL BIOPHYS, V25, P263
  • [6] Sodium channel Nav1.6 is localized at nodes of Ranvier, dendrites, and synapses
    Caldwell, JH
    Schaller, KL
    Lasher, RS
    Peles, E
    Levinson, SR
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2000, 97 (10) : 5616 - 5620
  • [7] Phytochemicals of Cinnamomi Cortex: Cinnamic Acid, but not Cinnamaldehyde, Attenuates Oxaliplatin-Induced Cold and Mechanical Hypersensitivity in Rats
    Chae, Hyeon Kyeong
    Kim, Woojin
    Kim, Sun Kwang
    [J]. NUTRIENTS, 2019, 11 (02):
  • [8] Analgesic Effect of Melittin on Oxaliplatin-Induced Peripheral Neuropathy in Rats
    Choi, Seunghwan
    Chae, Hyeon Kyeong
    Heo, Ho
    Hahm, Dae-Hyun
    Kim, Woojin
    Kim, Sun Kwang
    [J]. TOXINS, 2019, 11 (07)
  • [9] The roles of sodium channels in nociception: Implications for mechanisms of pain
    Cummins, Theodore R.
    Sheets, Patrick L.
    Waxman, Stephen G.
    [J]. PAIN, 2007, 131 (03) : 243 - 257
  • [10] Oxaliplatin-induced cold hypersensitivity is due to remodelling of ion channel expression in nociceptors
    Descoeur, Juliette
    Pereira, Vanessa
    Pizzoccaro, Anne
    Francois, Amaury
    Ling, Bing
    Maffre, Violette
    Couette, Brigitte
    Busserolles, Jerome
    Courteix, Christine
    Noel, Jacques
    Lazdunski, Michel
    Eschalier, Alain
    Authier, Nicolas
    Bourinet, Emmanuel
    [J]. EMBO MOLECULAR MEDICINE, 2011, 3 (05) : 266 - 278