GWAS-identified colorectal cancer susceptibility loci associated with clinical outcomes

被引：41
作者：
Dai, Jingyao
Gu, Jian
Huang, Maosheng
Eng, Cathy [2 ]
Kopetz, E. Scott [2 ]
Ellis, Lee M. [3 ,4 ]
Hawk, Ernest [5 ]
Wu, Xifeng [1 ]
机构：
[1] Univ Texas MD Anderson Canc Ctr, Dept Epidemiol, Unite1340, Houston, TX 77030 USA
[2] Univ Texas MD Anderson Canc Ctr, Dept Gastrointestinal Med Oncol, Houston, TX 77030 USA
[3] Univ Texas MD Anderson Canc Ctr, Dept Surg Oncol, Houston, TX 77030 USA
[4] Univ Texas MD Anderson Canc Ctr, Dept Canc Biol, Houston, TX 77030 USA
[5] Univ Texas MD Anderson Canc Ctr, Div Canc Prevent & Populat Sci, Houston, TX 77030 USA
来源：
CARCINOGENESIS | 2012年 / 33卷 / 07期
关键词：
GENOME-WIDE ASSOCIATION; BETA SIGNALING ALTERATIONS; COLON-CANCER; ADJUVANT TREATMENT; GENETIC-VARIANTS; PROSTATE-CANCER; CHROMOSOME; 8Q24; RISK; SCAN; FLUOROURACIL;
D O I：
10.1093/carcin/bgs147
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Recent genome-wide association studies (GWAS) have identified several common susceptibility loci associated with the risk of colorectal cancer (CRC). However, whether these loci affect clinical outcomes of CRC is not clear. In this study, we genotyped 26 single nucleotide polymorphisms (SNPs) in 10 GWAS-identified CRC susceptibility regions and evaluated their associations with survival and recurrence in 285 stage II and III patients receiving fluorouracil-based adjuvant chemotherapy. Only one SNP, rs10318 (15q13.3), was significantly associated with recurrence for patients with stage II disease. Three SNPs: rs10749971 (11q23.1), rs961253 (20p12.3) and rs355527 (20p12.3) in two regions were significantly associated with recurrence for patients with stage III disease. Five SNPs: rs961253 (20p12.3), rs355527 (20p12.3), rs4464148 (18q21.1), rs6983267 (8q24.21) and rs10505477 (8q24.21) in three regions were significantly associated with survival for patients with stage III disease. Cumulative effects of multiple unfavorable genotypes were observed for recurrence and survival in patients with stage III CRC. Our results suggest that cancer susceptibility loci may also affect the prognosis of CRC patients receiving fluorouracil-based adjuvant chemotherapy.
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页码：1327 / 1331
页数：5
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