Synthesis and Preliminary Antihyperlipidaemic Activities Evaluation of Andrographolide Derivatives

被引：8
作者：
Wang, Bin [1 ,2 ]
Tang, Chunlei [1 ]
Han, Yaodan [1 ]
Guo, Ruzhou [1 ]
Qian, Hai [1 ]
Huang, Wenlong [1 ]
机构：
[1] China Pharmaceut Univ, Sch Pharm, Ctr Drug Discovery, Nanjing 210009, Peoples R China
[2] Jiangsu Yabang Pharmaceut Grp, Ctr Technol, Changzhou 213163, Peoples R China
来源：
MEDICINAL CHEMISTRY | 2012年 / 8卷 / 02期
基金：
中国国家自然科学基金;
关键词：
Andrographolide; antihyperlipidaemic activities; derivatives; synthesis;
D O I：
10.2174/157340612800493629
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Recent studies indicated that andrographolide was a potential antihyperlipidaemic therapeutic agent. In the paper, the synthesis of a series of andrographolide derivatives was described and their antihyperlipidaemic activities were evaluated in vivo. As compared with TG, TC, HDL-C and LDL-C concentrations, some of the derivatives exhibited better antihyperlipidaemic effects than positive control atromide. Therein, compound 6i, which was the most potent compound, could serve as a new lead for further development of antihyperlipidaemic agents.
引用
收藏
页码：293 / 298
页数：6
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