Synthesis and Preliminary Antihyperlipidaemic Activities Evaluation of Andrographolide Derivatives

被引：8

作者：

Wang, Bin ^{[1
,2
]}

Tang, Chunlei ^{[1
]}

Han, Yaodan ^{[1
]}

Guo, Ruzhou ^{[1
]}

Qian, Hai ^{[1
]}

Huang, Wenlong ^{[1
]}

机构：

[1] China Pharmaceut Univ, Sch Pharm, Ctr Drug Discovery, Nanjing 210009, Peoples R China

[2] Jiangsu Yabang Pharmaceut Grp, Ctr Technol, Changzhou 213163, Peoples R China

来源：

MEDICINAL CHEMISTRY | 2012年 / 8卷 / 02期

基金：

中国国家自然科学基金;

关键词：

Andrographolide; antihyperlipidaemic activities; derivatives; synthesis;

D O I：

10.2174/157340612800493629

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Recent studies indicated that andrographolide was a potential antihyperlipidaemic therapeutic agent. In the paper, the synthesis of a series of andrographolide derivatives was described and their antihyperlipidaemic activities were evaluated in vivo. As compared with TG, TC, HDL-C and LDL-C concentrations, some of the derivatives exhibited better antihyperlipidaemic effects than positive control atromide. Therein, compound 6i, which was the most potent compound, could serve as a new lead for further development of antihyperlipidaemic agents.

引用

页码：293 / 298

页数：6

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