Synthesis and Preliminary Antihyperlipidaemic Activities Evaluation of Andrographolide Derivatives

被引：8
|
作者：
Wang, Bin [1 ,2 ]
Tang, Chunlei [1 ]
Han, Yaodan [1 ]
Guo, Ruzhou [1 ]
Qian, Hai [1 ]
Huang, Wenlong [1 ]
机构：
[1] China Pharmaceut Univ, Sch Pharm, Ctr Drug Discovery, Nanjing 210009, Peoples R China
[2] Jiangsu Yabang Pharmaceut Grp, Ctr Technol, Changzhou 213163, Peoples R China
来源：
MEDICINAL CHEMISTRY | 2012年 / 8卷 / 02期
基金：
中国国家自然科学基金;
关键词：
Andrographolide; antihyperlipidaemic activities; derivatives; synthesis;
D O I：
10.2174/157340612800493629
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
Recent studies indicated that andrographolide was a potential antihyperlipidaemic therapeutic agent. In the paper, the synthesis of a series of andrographolide derivatives was described and their antihyperlipidaemic activities were evaluated in vivo. As compared with TG, TC, HDL-C and LDL-C concentrations, some of the derivatives exhibited better antihyperlipidaemic effects than positive control atromide. Therein, compound 6i, which was the most potent compound, could serve as a new lead for further development of antihyperlipidaemic agents.
引用
收藏
页码：293 / 298
页数：6
相关论文
共 50 条
  • [1] Synthesis and Preliminary Anti-HIV Activities of Andrographolide Derivatives
    Wang, Bin
    Ge, Liang
    Huang, Wenlong
    Zhang, Huibin
    Qian, Hai
    Li, Jing
    Zheng, Yongtang
    MEDICINAL CHEMISTRY, 2010, 6 (04) : 252 - 258
  • [2] Synthesis and Preliminary COX-2 Expression Inhibitory Activities of Andrographolide Derivatives
    Li, Jing
    Huang, Wenlong
    Zhang, Huibin
    Zhou, Huiping
    LETTERS IN DRUG DESIGN & DISCOVERY, 2010, 7 (03) : 176 - 181
  • [3] Synthesis of andrographolide cyclophosphate derivatives and their antitumor activities
    Xu, HW
    Zhang, JY
    Liu, HM
    Wang, JF
    SYNTHETIC COMMUNICATIONS, 2006, 36 (04) : 407 - 414
  • [4] Recent Progress in Synthesis of Andrographolide Derivatives with Anti-tumor Activities
    Peng, Yuran
    Sun, Yicheng
    Wang, Decai
    Wei, Ping
    Ouyang, Pingkai
    Zhou, Guochun
    CHINESE JOURNAL OF ORGANIC CHEMISTRY, 2015, 35 (07) : 1451 - 1468
  • [5] The Synthesis and Preliminary Activity Assay In Vitro of Andrographolide Derivatives
    Xu, WeiDong
    Liu, Ya
    Tu, GuoGang
    Lai, XiaoPing
    Kuang, BinHai
    Li, ShaoHua
    LATIN AMERICAN JOURNAL OF PHARMACY, 2016, 35 (10): : 2234 - 2239
  • [6] Synthesis and Biological Evaluation of Andrographolide Derivatives as Potent Antibacterial Agents
    Tang, Chunlei
    Zhang, Wenjie
    Wang, Xinyang
    Wang, Bin
    Zhu, Xiaoyun
    Huang, Dandan
    Du, Xiaoyong
    Qian, Hai
    Huang, Wenlong
    Li, Jing
    LETTERS IN DRUG DESIGN & DISCOVERY, 2011, 8 (09) : 816 - 821
  • [7] Synthesis and Anti-HIV-Evaluation of Novel Andrographolide Derivatives
    Gu, Guolong
    Lin, Haiyan
    Liu, Yajuan
    Yang, Liumeng
    Zheng, Yongtang
    Wang, Bin
    Tang, Chunlei
    Qian, Hai
    Huang, Wenlong
    LETTERS IN DRUG DESIGN & DISCOVERY, 2013, 10 (02) : 155 - 163
  • [8] Synthesis of andrographolide derivatives and their TNF-α and IL-6 expression inhibitory activities
    Li, Jing
    Huang, Wenlong
    Zhang, Huibin
    Wang, Xinyang
    Zhou, Huiping
    BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2007, 17 (24) : 6891 - 6894
  • [9] Synthesis of 12-quinoline substituted andrographolide derivatives and their preliminary evaluation as anti-aggregation drugs
    Li, Xue
    Yu, Jiafeng
    Wu, Xianhao
    Hu, Cui
    Wang, Xiaoqing
    AUSTRALIAN JOURNAL OF CHEMISTRY, 2023, 76 (02) : 100 - 114
  • [10] Synthesis and biological evaluation of andrographolide derivatives as potent anti-HIV agents
    Bin Wang~a
    Chinese Chemical Letters, 2011, 22 (07) : 781 - 784
12345