Isoxazolone Derivatives as Potent Inhibitors of PTP1B

被引：23
作者：
Kafle, Bhooshan [1 ]
Cho, Hyeongjin [1 ]
机构：
[1] Inha Univ, Dept Chem, Coll Nat Sci, Inchon 402751, South Korea
来源：
BULLETIN OF THE KOREAN CHEMICAL SOCIETY | 2012年 / 33卷 / 01期
关键词：
Isoxazol-5(4H)-one; Protein tyrosine phosphatase; Inhibitor; PTP1B; TYROSINE-PHOSPHATASE; 1B; OBESITY; STRATEGIES; RESISTANCE; ACID;
D O I：
10.5012/bkcs.2012.33.1.275
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
[No abstract available]
引用
收藏
页码：275 / 277
页数：3
相关论文
共 17 条
[1]   Current and investigational antiobesity agents and obesity therapeutic treatment targets [J].
Bays, HE .
OBESITY RESEARCH, 2004, 12 (08) :1197-1211
[2]   2-O-Carboxymethylpyrogallol derivatives as PTP1B inhibitors with antihyperglycemic activity [J].
Bhattarai, Bharat Raj ;
Shresthaa, Suja ;
Ham, Seung Wook ;
Kim, Kwang Rok ;
Cheon, Hyae Gyeong ;
Lee, Keun-Hyeung ;
Cho, Hyeongjin .
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2007, 17 (19) :5357-5360
[3]   Novel thiazolidinedione derivatives with anti-obesity effects: Dual action as PTP1B inhibitors and PPAR-γ activators [J].
Bhattarai, Bharat Raj ;
Kafle, Bhooshan ;
Hwang, Ji-Sun ;
Ham, Seung Wook ;
Lee, Keun-Hyeung ;
Park, Hwangseo ;
Han, Inn-Oc ;
Cho, Hyeongjin .
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2010, 20 (22) :6758-6763
[4]   Antihyperglycemic Effects of Methylenedisalicylic Acid [J].
Bhattarai, Bharat Raj ;
Lee, Keun-Hyeung ;
Cho, Hyeongjin .
BULLETIN OF THE KOREAN CHEMICAL SOCIETY, 2009, 30 (12) :2879-2880
[5]   Thiazolidinedione derivatives as PTP1B inhibitors with antihyperglycemic and antiobesity effects [J].
Bhattarai, Bharat Raj ;
Kafle, Bhooshan ;
Hwang, Ji-Sun ;
Khadka, Deegendra ;
Lee, Sun-Myung ;
Kang, Jae-Seung ;
Ham, Seung Wook ;
Han, Inn-Oc ;
Park, Hwangseo ;
Cho, Hyeongjin .
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2009, 19 (21) :6161-6165
[6]   The obesity pipeline: current strategies in the development of anti-obesity drugs [J].
Cooke, Dunstan ;
Bloom, Steve .
NATURE REVIEWS DRUG DISCOVERY, 2006, 5 (11) :919-931
[7]   Increased insulin sensitivity and obesity resistance in mice lacking the protein tyrosine phosphatase-1B gene [J].
Elchebly, M ;
Payette, P ;
Michaliszyn, E ;
Cromlish, W ;
Collins, S ;
Loy, AL ;
Normandin, D ;
Cheng, A ;
Himms-Hagen, J ;
Chan, CC ;
Ramachandran, C ;
Gresser, MJ ;
Tremblay, ML ;
Kennedy, BP .
SCIENCE, 1999, 283 (5407) :1544-1548
[8]   Emerging therapeutic strategies for obesity [J].
Foster-Schubert, Karen E. ;
Cummings, David E. .
ENDOCRINE REVIEWS, 2006, 27 (07) :779-793
[9]   Cardiovascular morbidity and mortality associated with the metabolic syndrome [J].
Isomaa, B ;
Almgren, P ;
Tuomi, T ;
Forsén, B ;
Lahti, K ;
Nissén, M ;
Taskinen, MR ;
Groop, L .
DIABETES CARE, 2001, 24 (04) :683-689
[10]   Type 2 diabetes mellitus-Its global prevalence and therapeutic strategies [J].
Jain, Shelesh ;
Saraf, Swarnlata .
DIABETES & METABOLIC SYNDROME-CLINICAL RESEARCH & REVIEWS, 2010, 4 (01) :48-56
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