Activity and inducibility of cytochrome P-450-1A in the liver of mice with different sensitivity to hepatocarcinogenic effect of o-aminoazotoluene

被引：1

作者：

Gulyaeva, LF

Zakharova, LY

Lyakhovich, VV

Morozkova, TS

Kaledin, VI

机构：

[1] Russian Acad Med Sci, Inst Mol Pathol & Ecol Biochem, Siberian Div, Novosibirsk, Russia

[2] Russian Acad Sci, Inst Cytol & Genet, Siberian Div, Novosibirsk 630090, Russia

来源：

BULLETIN OF EXPERIMENTAL BIOLOGY AND MEDICINE | 1998年 / 126卷 / 08期

关键词：

inbred mice; O-aminoazotoleune; induction; cytochrome P-450-1a;

D O I：

10.1007/BF02446920

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Specific activity of cytochrome P-450-1a is detected in the liver of 7 inbred mouse strains sensitive (SWR, C3HA, DD, and CBA) and resistant (AKR, CC57BR, and C57BL) to o-aminoazotoluene-induced hepatocarcinogenesis: 7-ethoxyresorufin-O-diethylase a nd 7-methoxyresorufin-O-dimethylase, induced by benzo(a)pyre ne and o-aminoazotoluene. Mice sensitive (CC57BR and C57BL) and resistant (AKR) to P-450-1a induction were resistant to induction of liver tumor and, similarly, mice both resistant (SWR and DD) and sensitive (C3HA and CBA) to P-450-1a induction were sensitive to hepatic tumor induction. Therefore, there was no correlation between inducibility of cytochrome P-450-1a and sensitivity to o-aminoazotoluene-induced hepatocarcinogenesis at the initial stages of chemical carcinogenesis.

引用

页码：820 / 822

页数：3