The inducible E3 ubiquitin ligases SIAH1 and SIAH2 perform critical roles in breast and prostate cancers

被引：30
作者：
Knauer, Shirley K. [1 ]
Mahendrarajah, Nisintha [2 ]
Roos, Wynand P. [2 ]
Kraemer, Oliver H. [2 ]
机构：
[1] Univ Duisburg Essen, Ctr Med Biotechnol ZMB, Dept Mol Biol, D-45141 Essen, Germany
[2] Univ Med Ctr, Dept Toxicol, D-55131 Mainz, Germany
来源：
CYTOKINE & GROWTH FACTOR REVIEWS | 2015年 / 26卷 / 04期
关键词：
Cytokine; Estrogen; Sex hormone; SIAH1; SIAH2; FACTOR RECEPTOR EXPRESSION; ABSENTIA HOMOLOG 2; DOWN-REGULATION; P53; RESISTANCE; STABILITY; APOPTOSIS; PATHWAY; GROWTH; IDENTIFICATION;
D O I：
10.1016/j.cytogfr.2015.04.002
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The ubiquitin-dependent proteasomal degradation of proteins controls signaling and cellular survival. An increasing body of evidence suggests that the E3 ubiquitin ligases SIAH1 and S1AH2 are able to dictate the growth, development, and chemo-/radiosensitivity of breast and prostate cancer cells. Here we review the current knowledge on the impact of S1AHs on breast and prostate tumorigenesis. Furthermore, we summarize how stress, hormones, and cytokines regulate SIAH1 and SIAH2 in transformed mammalian cells. (C) 2015 Elsevier Ltd. All rights reserved.
引用
收藏
页码：405 / 413
页数：9
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