The inducible E3 ubiquitin ligases SIAH1 and SIAH2 perform critical roles in breast and prostate cancers

被引：30
作者：
Knauer, Shirley K. [1 ]
Mahendrarajah, Nisintha [2 ]
Roos, Wynand P. [2 ]
Kraemer, Oliver H. [2 ]
机构：
[1] Univ Duisburg Essen, Ctr Med Biotechnol ZMB, Dept Mol Biol, D-45141 Essen, Germany
[2] Univ Med Ctr, Dept Toxicol, D-55131 Mainz, Germany
来源：
CYTOKINE & GROWTH FACTOR REVIEWS | 2015年 / 26卷 / 04期
关键词：
Cytokine; Estrogen; Sex hormone; SIAH1; SIAH2; FACTOR RECEPTOR EXPRESSION; ABSENTIA HOMOLOG 2; DOWN-REGULATION; P53; RESISTANCE; STABILITY; APOPTOSIS; PATHWAY; GROWTH; IDENTIFICATION;
D O I：
10.1016/j.cytogfr.2015.04.002
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The ubiquitin-dependent proteasomal degradation of proteins controls signaling and cellular survival. An increasing body of evidence suggests that the E3 ubiquitin ligases SIAH1 and S1AH2 are able to dictate the growth, development, and chemo-/radiosensitivity of breast and prostate cancer cells. Here we review the current knowledge on the impact of S1AHs on breast and prostate tumorigenesis. Furthermore, we summarize how stress, hormones, and cytokines regulate SIAH1 and SIAH2 in transformed mammalian cells. (C) 2015 Elsevier Ltd. All rights reserved.
引用
收藏
页码：405 / 413
页数：9
相关论文
共 96 条
  • [1] Effect of Disrupting Seven-in-Absentia Homolog 2 Function on Lung Cancer Cell Growth
    Ahmed, Atique U.
    Schmidt, Rebecca L.
    Park, Cheol Hong
    Reed, Nanette R.
    Hesse, Shayla E.
    Thomas, Charles F.
    Molina, Julian R.
    Deschamps, Claude
    Yang, Ping
    Aubry, Marie C.
    Tang, Amy H.
    [J]. JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE, 2008, 100 (22): : 1606 - 1629
  • [2] Isolation of 10 differentially expressed cDNAs in p53-induced apoptosis: Activation of the vertebrate homologue of the Drosophila seven in absentia gene
    Amson, RB
    Nemani, M
    Roperch, JP
    Israeli, D
    Bougueleret, L
    LeGall, I
    Medhioub, M
    LinaresCruz, G
    Lethrosne, F
    Pasturaud, P
    Piouffre, L
    Prieur, S
    Susini, L
    Alvaro, V
    Millasseau, P
    Guidicelli, C
    Bui, H
    Massart, C
    Cazes, L
    Dufour, F
    BruzzoniGiovanelli, H
    Owadi, H
    Hennion, C
    Charpak, G
    Dausset, J
    Calvo, F
    Oren, M
    Cohen, D
    Telerman, A
    [J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1996, 93 (09) : 3953 - 3957
  • [3] Aschelter Anna M, 2012, Front Endocrinol (Lausanne), V3, P128, DOI 10.3389/fendo.2012.00128
  • [4] Molecularly targeted therapies for metastatic triple-negative breast cancer
    Bayraktar, Soley
    Glueck, Stefan
    [J]. BREAST CANCER RESEARCH AND TREATMENT, 2013, 138 (01) : 21 - 35
  • [5] Increased SIAH expression predicts ductal carcinoma in situ (DCIS) progression to invasive carcinoma
    Behling, Kathryn C.
    Tang, Amy
    Freydin, Boris
    Chervoneva, Inna
    Kadakia, Sameep
    Schwartz, Gordon F.
    Rui, Hallgeir
    Witkiewicz, Agnieszka K.
    [J]. BREAST CANCER RESEARCH AND TREATMENT, 2011, 129 (03) : 717 - 724
  • [6] Differences and molecular immunohistochemical parameters in the subtypes of infiltrating ductal breast cancer
    Bertolo, Cristina
    Guerrero, David
    Vicente, Francisco
    Cordoba, Alicia
    Esteller, Manel
    Ropero, Santiago
    Guillen-Grima, Francisco
    Maria Martinez-Penuela, Jose
    Miguel Lera, Jose
    [J]. AMERICAN JOURNAL OF CLINICAL PATHOLOGY, 2008, 130 (03) : 414 - 424
  • [7] Basal Breast Cancer: A Complex and Deadly Molecular Subtype
    Bertucci, F.
    Finetti, P.
    Birnbaum, D.
    [J]. CURRENT MOLECULAR MEDICINE, 2012, 12 (01) : 96 - 110
  • [8] SIAH-1 inhibits cell growth by altering the mitotic process
    Bruzzoni-Giovanelli, H
    Faille, A
    Linares-Cruz, G
    Nemani, M
    Le Deist, F
    Germani, A
    Chassoux, D
    Millot, G
    Roperch, JP
    Amson, R
    Telerman, A
    Calvo, F
    [J]. ONCOGENE, 1999, 18 (50) : 7101 - 7109
  • [9] Distinct expression patterns of the E3 ligase SIAH-1 and its partner Kid/KIF22 in normal tissues and in the breast tumoral processes
    Bruzzoni-Giovanelli, Heriberto
    Fernandez, Plinio
    Veiga, Lucia
    Podgorniak, Marie-Pierre
    Powell, Darren J.
    Candeias, Marco M.
    Mourah, Samia
    Calvo, Fabien
    Marin, Monica
    [J]. JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH, 2010, 29
  • [10] SIAH ubiquitin ligases target the nonreceptor tyrosine kinase ACK1 for ubiquitinylation and proteasomal degradation
    Buchwald, M.
    Pietschmann, K.
    Brand, P.
    Guenther, A.
    Mahajan, N. P.
    Heinzel, T.
    Kraemer, O. H.
    [J]. ONCOGENE, 2013, 32 (41) : 4913 - 4920
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