The inducible E3 ubiquitin ligases SIAH1 and SIAH2 perform critical roles in breast and prostate cancers

被引：30
|
作者：
Knauer, Shirley K. [1 ]
Mahendrarajah, Nisintha [2 ]
Roos, Wynand P. [2 ]
Kraemer, Oliver H. [2 ]
机构：
[1] Univ Duisburg Essen, Ctr Med Biotechnol ZMB, Dept Mol Biol, D-45141 Essen, Germany
[2] Univ Med Ctr, Dept Toxicol, D-55131 Mainz, Germany
来源：
CYTOKINE & GROWTH FACTOR REVIEWS | 2015年 / 26卷 / 04期
关键词：
Cytokine; Estrogen; Sex hormone; SIAH1; SIAH2; FACTOR RECEPTOR EXPRESSION; ABSENTIA HOMOLOG 2; DOWN-REGULATION; P53; RESISTANCE; STABILITY; APOPTOSIS; PATHWAY; GROWTH; IDENTIFICATION;
D O I：
10.1016/j.cytogfr.2015.04.002
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The ubiquitin-dependent proteasomal degradation of proteins controls signaling and cellular survival. An increasing body of evidence suggests that the E3 ubiquitin ligases SIAH1 and S1AH2 are able to dictate the growth, development, and chemo-/radiosensitivity of breast and prostate cancer cells. Here we review the current knowledge on the impact of S1AHs on breast and prostate tumorigenesis. Furthermore, we summarize how stress, hormones, and cytokines regulate SIAH1 and SIAH2 in transformed mammalian cells. (C) 2015 Elsevier Ltd. All rights reserved.
引用
收藏
页码：405 / 413
页数：9
相关论文
共 50 条
  • [1] Investigating the Molecular Basis of Siah1 and Siah2 E3 Ubiquitin Ligase Substrate Specificity
    Gopalsamy, Anupriya
    Hagen, Thilo
    Swaminathan, Kunchithapadam
    PLOS ONE, 2014, 9 (09):
  • [2] Differential regulation of PML-RARet stability by the ubiquitin ligases SIAH1/SIAH2 and TRIAD1
    Pietschmann, Kristin
    Buchwald, Marc
    Mueller, Sylvia
    Knauer, Shirley K.
    Koegl, Manfred
    Heinzel, Thorsten
    Kraemer, Oliver H.
    INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY, 2012, 44 (01): : 132 - 138
  • [3] Fine Tuning of the UPR by the Ubiquitin Ligases Siah1/2
    Scortegagna, Marzia
    Kim, Hyungsoo
    Li, Jian-Liang
    Yao, Hang
    Brill, Laurence M.
    Han, Jaeseok
    Lau, Eric
    Bowtell, David
    Haddad, Gabriel
    Kaufman, Randal J.
    Ronai, Ze'ev A.
    PLOS GENETICS, 2014, 10 (05):
  • [4] Possible role of death receptor-mediated apoptosis by the E3 ubiquitin ligases Siah2 and POSH
    Perry A Christian
    Michael V Fiandalo
    Steven R Schwarze
    Molecular Cancer, 10
  • [5] Regulation of MYPT1 stability by the E3 ubiquitin ligase SIAH2
    Twomey, Erin
    Li, Yan
    Lei, Joy
    Sodja, Caroline
    Ribecco-Lutkiewicz, Maria
    Smith, Brandon
    Fang, Hung
    Bani-Yaghoub, Mahmud
    McKinnell, Iain
    Sikorska, Marianna
    EXPERIMENTAL CELL RESEARCH, 2010, 316 (01) : 68 - 77
  • [6] The E3 Ubiquitin Ligases Siah2 Contributes To Imatinib Resistance In Chronic Myeloid Leukemia In Hypoxia Condition
    Xu, Na
    Xiao, Xiaozhen
    Xiao, Yajuan
    Zhou, Xuan
    Gao, Guanlun
    Huang, Fen
    Xu, Dan
    Zhou, Hongsheng
    Xu, Bing
    Liu Xiaoli
    BLOOD, 2013, 122 (21)
  • [7] Possible role of death receptor-mediated apoptosis by the E3 ubiquitin ligases Siah2 and POSH
    Christian, Perry A.
    Fiandalo, Michael V.
    Schwarze, Steven R.
    MOLECULAR CANCER, 2011, 10
  • [8] The Ubiquitin E3 Ligase Siah2 Regulates PPARγ Activity in Adipocytes
    Kilroy, Gail
    Mynatt, Randall L.
    Floyd, Z. Elizabeth
    DIABETES, 2011, 60 : A125 - A125
  • [9] SIAH ubiquitin E3 ligases as modulators of inflammatory gene expression
    Schmitz, Lienhard
    Dreute, Jan
    Pfisterer, Maximilian
    Guenther, Stefan
    Kracht, Michael
    Chillappagari, Shashipavan
    HELIYON, 2022, 8 (03)
  • [10] CHK2 stability is regulated by the E3 ubiquitin ligase SIAH2
    C García-Limones
    M Lara-Chica
    C Jiménez-Jiménez
    M Pérez
    P Moreno
    E Muñoz
    M A Calzado
    Oncogene, 2016, 35 : 4289 - 4301
12345