Direct Oxidative C-P Bond Formation of Indoles with Dialkyl Phosphites

被引：49

作者：

Wang, Haolong ^{[1
]}

Li, Xincheng ^{[1
]}

Wu, Fan ^{[1
]}

Wan, Boshun ^{[1
]}

机构：

[1] Chinese Acad Sci, Dalian Inst Chem Phys, Dalian 116023, Peoples R China

来源：

SYNTHESIS-STUTTGART | 2012年 / 44卷 / 06期

关键词：

indole; dialkyl phosphite; phosphonation; silver acetate; oxidative coupling; CROSS-COUPLING REACTIONS; PHOSPHORUS-CARBON BOND; AROMATIC-COMPOUNDS; ACIDS; PHOSPHONATION; PHOSPHONYLATION; DERIVATIVES; CYCLIZATION;

D O I：

10.1055/s-0031-1289700

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The direct phosphonation of indoles was developed. In this reaction, dialkyl phosphites and indoles were used as substrates, and the C-P bond was formed through oxidative coupling mediated by silver(I) acetate. Various indoles and different dialkyl phosphites were effective substrates for the reaction, and dialkylphosphoryl-substituted indoles were obtained in up to 71% yield.

引用

页码：941 / 945

页数：5

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