Serum and CSF measles antibody levels increase over time in patients with multiple sclerosis or clinically isolated syndrome

被引：16

作者：

Ahlgren, Cecilia ^{[1
]}

Oden, Anders ^{[2
]}

Bergstrom, Tomas ^{[3
]}

Lycke, Jan ^{[1
]}

机构：

[1] Sahlgrens Univ Hosp, Dept Neurol, Inst Neurosci & Physiol, S-41345 Gothenburg, Sweden

[2] Chalmers, Dept Math Sci, Inst Stat Math, S-41296 Gothenburg, Sweden

[3] Sahlgrens Univ Hosp, Dept Virol, Inst Biomed, S-41345 Gothenburg, Sweden

来源：

JOURNAL OF NEUROIMMUNOLOGY | 2012年 / 247卷 / 1-2期

关键词：

Multiple sclerosis; Epidemiology; Measles virus antibodies; CSF; Polyspecific immune response; Duration of disease; EPSTEIN-BARR-VIRUS; B-CELL FOLLICLES; CEREBROSPINAL-FLUID; IMMUNE-RESPONSE; MATCHED CONTROLS; RUBELLA; INFLAMMATION; INFECTION; RITUXIMAB; VACCINE;

D O I：

10.1016/j.jneuroim.2012.03.014

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

In general, measles virus (MV) immunoglobulin G (IgG) antibody titres decline over time. However, we found that serum and CSF MV antibody titres increased with age (slope=0.038, p<0.001 and slope=0.022, p=0.008), respectively, and disease duration (slope=0.031, p=0.002 and slope=0.032, p=0.005), respectively, in patients with multiple sclerosis (MS) or clinically isolated syndrome (CIS). The age dependency of serum antibody levels differed between patients and controls (slope=0.038 versus -0.004, p<0.001). The increasing MV antibody litres over time in MS/CIS patients support a general nonspecific stimulation of B cells and plasma cells that is not confined only to the CNS/CSF compartment. (c) 2012 Elsevier B.V. All rights reserved.

引用

页码：70 / 74

页数：5

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