Biophysical approaches to G protein-coupled receptors: Structure, function and dynamics

被引：13

作者：

Chollet, A ^{[1
]}

Turcatti, G ^{[1
]}

机构：

[1] Serono Pharmaceut Res Inst, CH-1228 Geneva, Switzerland

来源：

JOURNAL OF COMPUTER-AIDED MOLECULAR DESIGN | 1999年 / 13卷 / 03期

关键词：

electron paramagnetic resonance (EPR); fluorescence resonance energy transfer (FRET); ligand-receptor interactions; neurokinin receptors; nonsense suppression mutagenesis; rhodopsin;

D O I：

10.1023/A:1008052002695

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

G protein-coupled receptors (GPCR) represent a large family of drug targets for which there is no high-resolution structural information. In order to understand the mechanisms of ligand recognition and receptor activation, there is a strong need for novel biophysical methods. In this Perspective we provide an overview of recent experimental approaches used to explore the molecular architecture and dynamics of GPCR and their interactions with ligands and G proteins using biophysical, non-crystallographic, methods.

引用

页码：209 / 219

页数：11

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