Cytokines in rotator cuff degeneration and repair

被引:85
作者
Bedi, Asheesh [1 ]
Maak, Travis [2 ]
Walsh, Christopher [1 ]
Rodeo, Scott A. [2 ]
Grande, Dan [3 ]
Dines, David M. [2 ,3 ]
Dines, Joshua S. [2 ,3 ]
机构
[1] Univ Michigan, Dept Orthopaed Surg, Ann Arbor, MI 48106 USA
[2] Hosp Special Surg, Sports Med & Shoulder Serv, New York, NY 10021 USA
[3] Long Isl Jewish Med Ctr, Shoulder Surg Serv, Long Isl City, NY USA
关键词
Rotator cuff injury; tendinopathy; growth factors; inflammation; cytokines; bone morphogenetic proteins; FIBROBLAST-GROWTH-FACTOR; INTENSITY PULSED ULTRASOUND; BONE MORPHOGENETIC PROTEIN; MEDIAL COLLATERAL LIGAMENT; CONTROLLED CLINICAL-TRIAL; RABBIT FLEXOR TENDON; MESSENGER-RNA LEVELS; RAT ACHILLES-TENDON; SUPRASPINATUS TENDON; FACTOR-I;
D O I
10.1016/j.jse.2011.09.020
中图分类号
R826.8 [整形外科学]; R782.2 [口腔颌面部整形外科学]; R726.2 [小儿整形外科学]; R62 [整形外科学(修复外科学)];
学科分类号
摘要
The pathogenesis of rotator cuff degeneration remains poorly defined, and the incidence of degenerative tears is increasing in the aging population. Rates of recurrent tear and incomplete tendon-to-bone healing after repair remain significant for large and massive tears. Previous studies have documented a disorganized, fibrous junction at the tendon-to-bone interface after rotator cuff healing that does not recapitulate the organization of the native enthesis. Many biologic factors have been implicated in coordinating tendon-to-bone healing and maintenance of the enthesis after rotator cuff repair, including the expression and activation of transforming growth factor-beta, basic fibroblast growth factor, platelet-derived growth factor-beta, matrix metalloproteinases, and tissue inhibitors of metalloproteinases. Future techniques to treat tendinopathy and enhance tendon-to-bone healing will be driven by our understanding of the biology of this healing process after rotator cuff repair surgery. The use of cytokines to provide important signals for tissue formation and differentiation, the use of gene therapy techniques to provide sustained cytokine delivery, the use of stem cells, and the use of transcription factors to modulate endogenous gene expression represent some of these possibilities. Level of evidence: Review Article. (C) 2012 Journal of Shoulder and Elbow Surgery Board of Trustees.
引用
收藏
页码:218 / 227
页数:10
相关论文
共 113 条
[1]   RECOMBINANT HUMAN INSULIN-LIKE GROWTH FACTOR-I STIMULATES INVITRO MATRIX SYNTHESIS AND CELL-PROLIFERATION IN RABBIT FLEXOR TENDON [J].
ABRAHAMSSON, SO ;
LUNDBORG, G ;
LOHMANDER, LS .
JOURNAL OF ORTHOPAEDIC RESEARCH, 1991, 9 (04) :495-502
[2]   Differential effects of insulin-like growth factor-I on matrix and DNA synthesis in various regions and types of rabbit tendons [J].
Abrahamsson, SO ;
Lohmander, S .
JOURNAL OF ORTHOPAEDIC RESEARCH, 1996, 14 (03) :370-376
[3]   LONG-TERM EXPLANT CULTURE OF RABBIT FLEXOR TENDON - EFFECTS OF RECOMBINANT HUMAN INSULIN-LIKE GROWTH FACTOR-I AND SERUM ON MATRIX METABOLISM [J].
ABRAHAMSSON, SO ;
LUNDBORG, G ;
LOHMANDER, LS .
JOURNAL OF ORTHOPAEDIC RESEARCH, 1991, 9 (04) :503-515
[4]  
ABRAHAMSSON SO, 1991, SCAND J PLAST RECONS, pUR1
[5]  
ARNER O, 1959, Acta Chir Scand Suppl, V116, P1
[6]   Bone morphogenetic proteins and tendon repair [J].
Aspenberg, P ;
Forslund, C .
SCANDINAVIAN JOURNAL OF MEDICINE & SCIENCE IN SPORTS, 2000, 10 (06) :372-375
[7]   Enhanced tendon healing with GDF 5 and 6 [J].
Aspenberg, P ;
Forslund, C .
ACTA ORTHOPAEDICA SCANDINAVICA, 1999, 70 (01) :51-54
[8]   Bone morphogenetic proteins in orthopaedic surgery [J].
Axelrad, T. William ;
Einhorn, Thomas A. .
CYTOKINE & GROWTH FACTOR REVIEWS, 2009, 20 (5-6) :481-488
[9]   Diabetes mellitus impairs tendon-bone healing after rotator cuff repair [J].
Bedi, Asheesh ;
Fox, Alice J. S. ;
Harris, Paul E. ;
Deng, Xiang-Hua ;
Ying, Liang ;
Warren, Russell F. ;
Rodeo, Scott A. .
JOURNAL OF SHOULDER AND ELBOW SURGERY, 2010, 19 (07) :978-988
[10]   The effect of matrix metalloproteinase inhibition on tendon-to-bone healing in a rotator cuff repair model [J].
Bedi, Asheesh ;
Kovacevic, David ;
Hettrich, Carolyn ;
Gulotta, Lawrence V. ;
Ehteshami, John R. ;
Warren, Russell F. ;
Rodeo, Scott A. .
JOURNAL OF SHOULDER AND ELBOW SURGERY, 2010, 19 (03) :384-391