Targeting of CDK7 inhibits super-enhancer-associated oncogenic programs in MYCN-amplified tumor cells

被引：0
|
作者：
Chipumuro, Edmond
Marco, Eugenio
Christensen, Camilla L.
Kwiatkowski, Nicholas
Zhang, Tinghu
Hatheway, Clark M.
Abraham, Brian J.
Sharma, Bandana
Yeung, Caleb
Altabef, Abigail
Perez-Atayde, Antonio
Wong, Kwok-Kin
Yuan, Guo-Cheng
Gray, Nathanael S.
Young, Richard A.
George, Rani E.
机构：
来源：
MOLECULAR CANCER RESEARCH | 2015年 / 13卷
关键词：
D O I：
10.1158/1557-3125.MYC15-PR05
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
PR05
引用
收藏
页数：2
相关论文
共 22 条
  • [1] Effect of CDK7 inhibitor on MYCN-amplified retinoblastoma
    Xu, Hanyue
    Xiao, Lirong
    Chen, Yi
    Liu, Yilin
    Zhang, Yifan
    Gao, Yuzhu
    Man, Shulei
    Yan, Naihong
    Zhang, Ming
    BIOCHIMICA ET BIOPHYSICA ACTA-GENE REGULATORY MECHANISMS, 2023, 1866 (03):
  • [2] CDK7 blockade suppresses super-enhancer-associated oncogenes in bladder cancer
    Yang, Yafei
    Jiang, Donggen
    Zhou, Ziyu
    Xiong, Haiyun
    Yang, Xiangwei
    Peng, Guoyu
    Xia, Wuchao
    Wang, Shang
    Lei, Hanqi
    Zhao, Jing
    Qian, Zhirong
    Wu, Song
    Pang, Jun
    CELLULAR ONCOLOGY, 2021, 44 (04) : 871 - 887
  • [3] Targeting Super-Enhancer-Associated Oncogenes in Osteosarcoma with THZ2, a Covalent CDK7 Inhibitor
    Zhang, Jiajun
    Liu, Weihai
    Zou, Changye
    Zhao, Zhiqiang
    Lai, Yuanying
    Shi, Zhi
    Xie, Xianbiao
    Huang, Gang
    Wang, Yongqian
    Zhang, Xuelin
    Fan, Zepei
    Su, Qiao
    Yin, Junqiang
    Shen, Jingnan
    CLINICAL CANCER RESEARCH, 2020, 26 (11) : 2681 - 2692
  • [4] CDK7 Inhibition Suppresses Super-Enhancer-Linked Oncogenic Transcription in MYCN-Driven Cancer
    Chipumuro, Edmond
    Marco, Eugenio
    Christensen, Camilla L.
    Kwiatkowski, Nicholas
    Zhang, Tinghu
    Hatheway, Clark M.
    Abraham, Brian J.
    Sharma, Bandana
    Yeung, Caleb
    Altabef, Abigail
    Perez-Atayde, Antonio
    Wong, Kwok-Kin
    Yuan, Guo-Cheng
    Gray, Nathanael S.
    Young, Richard A.
    George, Rani E.
    CELL, 2014, 159 (05) : 1126 - 1139
  • [5] Targeting Super-Enhancer-Driven Oncogenic Transcription by CDK7 Inhibition in Anaplastic Thyroid Carcinoma
    Cao, Xinyi
    Dang, Lin
    Zheng, Xiangqian
    Lu, Yi
    Lu, Yumei
    Ji, Rongjie
    Zhang, Tianye
    Ruan, Xianhui
    Zhi, Jingtai
    Hou, Xiukun
    Yi, Xianfu
    Li, Mulin Jun
    Gu, Tingyu
    Gao, Ming
    Zhang, Lirong
    Chen, Yupeng
    THYROID, 2019, 29 (06) : 809 - 823
  • [6] Targeting amplified MYCN through CDK7 inhibition in high-risk neuroblastoma
    George, Rani
    CANCER RESEARCH, 2016, 76
  • [7] RETRACTION: Targeting MYCN IRES in MYCN-amplified Neuroblastoma With Mir-375 Inhibits Tumor Growth and Sensitizes Tumor Cells to Radiation
    Zhang, H.
    Liu, T.
    Yi, S.
    Gu, L.
    Zhou, M.
    MOLECULAR ONCOLOGY, 2025, 19 (01) : 261 - 261
  • [8] USP7 TARGETING MAY SUPPRESS MYCN-AMPLIFIED TUMOR GROWTH
    不详
    CANCER DISCOVERY, 2016, 6 (11) : 1209 - 1209
  • [9] CDK7 blockade suppresses super‐enhancer‐associated oncogenes in bladder cancer
    Yafei Yang
    Donggen Jiang
    Ziyu Zhou
    Haiyun Xiong
    Xiangwei Yang
    Guoyu Peng
    Wuchao Xia
    Shang Wang
    Hanqi Lei
    Jing Zhao
    Zhirong Qian
    Song Wu
    Jun Pang
    Cellular Oncology, 2021, 44 : 871 - 887
  • [10] Perturbation of CDK7 and super-enhancer driven transcriptional programs synergistically halts multiple myeloma cell proliferation
    Yao, Yao
    Park, Woojun D.
    Morelli, Eugenio
    Samur, Mehmet K.
    Kwiatkowski, Nicholas
    Xu, Yan
    Nabet, Behnam
    Chakraborty, Chandraditya
    Chesi, Marta
    Gray, Nathaniel
    Young, Rick
    Anderson, Kenneth
    Lin, Charles
    Munshi, Nikhil C.
    Fulciniti, Mariateresa
    CLINICAL LYMPHOMA MYELOMA & LEUKEMIA, 2021, 21 : S93 - S93
123