Bioinformatics and Network Pharmacology-Based Approaches to Explore the Potential Mechanism of the Antidepressant Effect of Cyperi Rhizoma through Soothing the Liver

被引:4
|
作者
Lei, Yuhe [1 ]
Du, Mingquan [2 ]
Zhang, Ge [3 ]
Chen, Lei [1 ]
Fu, Yanli [4 ]
Zhong, Yinqin [5 ]
Zhang, Enxin [5 ]
机构
[1] Guangzhou Univ Chinese Med, Dept Pharm, Shenzhen Hosp, Shenzhen 518032, Guangdong, Peoples R China
[2] Futian Ctr Chron Dis Control, Dept Pharm, Shenzhen 518000, Guangdong, Peoples R China
[3] Guangdong Prov Hosp Chinese Med, Chinese Med Dev Res Ctr, Guangzhou 510120, Guangdong, Peoples R China
[4] Guangzhou Univ Chinese Med, Dept Oncol, Shenzhen Hosp, Shenzhen 518032, Guangdong, Peoples R China
[5] Guangzhou Univ Chinese Med, Shenzhen Hosp, Shenzhen 518032, Guangdong, Peoples R China
基金
中国国家自然科学基金;
关键词
PLASMINOGEN-ACTIVATOR INHIBITOR-1; GLYCATION END-PRODUCTS; DEPRESSION; EXPRESSION; ROTUNDUS; STRESS; SCHIZOPHRENIA; INFLAMMATION; METABOLISM; GLYCOSIDES;
D O I
10.1155/2021/8614963
中图分类号
R [医药、卫生];
学科分类号
10 ;
摘要
Major depressive disorder (MDD) has become the second most common disease worldwide, making it a threat to human health. Cyperi Rhizoma (CR) is a traditional herbal medicine with antidepressant properties. Traditional Chinese medicine theory states that CR relieves MDD by dispersing stagnated liver qi to soothe the liver, but the material basis and underlying mechanism have not been elucidated. In this study, we identified the active compounds and potential anti-MDD targets of CR by network pharmacology-based approaches. Through Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment analysis, we hypothesized that the anti-MDD effect of CR may be mediated by an altered response of the liver to lipopolysaccharide (LPS) and glucose metabolism. Through bioinformatics analysis, comparing normal and MDD liver tissue in rats with spontaneous diabetes, we identified differentially expressed genes (DEGs) and selected PAI-1 (SERPINE1) as a target of CR in combating MDD. Molecular docking and molecular dynamics analysis also verified the binding of the active compound quercetin to PAI-1. It can be concluded that quercetin is the active compound of CR that acts against MDD by targeting PAI-1 to enhance the liver response to LPS and glucose metabolism. This study not only reveals the material basis and underlying mechanism of CR against MDD through soothing the liver but also provides evidence for PAI-1 as a potential target and quercetin as a potential agent for MDD treatment.
引用
收藏
页数:13
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