Kisspeptin and GPR54: Discovery of a novel pathway in reproduction

被引：62
作者：
Seminara, S. B. [1 ]
Crowley, W. F., Jr. [1 ]
机构：
[1] Massachusetts Gen Hosp, Harvard Partners Reprod Sci Ctr, Reprod Endocrine Unit, Boston, MA 02114 USA
来源：
JOURNAL OF NEUROENDOCRINOLOGY | 2008年 / 20卷 / 06期
关键词：
kisspeptin; GPR54; metastin; genetics; hypogonadotrophic hypogonadism;
D O I：
10.1111/j.1365-2826.2008.01731.x
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
In order to find novel modulators of gonadotrophin-releasing hormone (GnRH) secretion, genetic tools were employed in patients with idiopathic hypogonadotrophic hypogonadism (IHH). Mutations in a G-protein coupled receptor, GPR54, were identified, making this receptor a genetic determinant and indisputable gatekeeper of normal reproductive function. This article places these investigations into historical context and reviews some of the new findings relevant to this pathway.
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收藏
页码：727 / 731
页数：5
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