Inhibitors targeting two-component signal transduction

被引:0
作者
Watanabe, Takafumi [1 ]
Okada, Ario [1 ]
Gotoh, Yasuhiro [1 ]
Utsumi, Ryutaro [1 ]
机构
[1] Kinki Univ, Grad Sch Agr, Dept Biosci, Nara 6318505, Japan
来源
BACTERIAL SIGNAL TRANSDUCTION: NETWORKS AND DRUG TARGETS | 2008年 / 631卷
关键词
D O I
暂无
中图分类号
R-3 [医学研究方法]; R3 [基础医学];
学科分类号
1001 ;
摘要
A two-component signal transduction system (TCS) is an attractive target for antibacterial agents. In this chapter, we review the TCS inhibitors developed during the past decade and introduce novel drug discovery systems to isolate the inhibitors of the YycG/YycF system, an essential TCS for bacterial growth, in an effort to develop a new class of antibacterial agents.
引用
收藏
页码:229 / 236
页数:8
相关论文
共 50 条
[42]   Genomic Analysis of Two-Component Signal Transduction Proteins in Basidiomycetes [J].
Lavin, Jose L. ;
Ramirez, Lucia ;
Ussery, David W. ;
Pisabarro, Antonio G. ;
Oguiza, Jose A. .
JOURNAL OF MOLECULAR MICROBIOLOGY AND BIOTECHNOLOGY, 2010, 18 (02) :63-73
[43]   A developmentally regulated two-component signal transduction system in Chlamydia [J].
Koo, IC ;
Stephens, RS .
JOURNAL OF BIOLOGICAL CHEMISTRY, 2003, 278 (19) :17314-17319
[44]   The role of sensory kinase proteins in two-component signal transduction [J].
Alvarez, Adrian F. ;
Georgellis, Dimitris .
BIOCHEMICAL SOCIETY TRANSACTIONS, 2022, :1859-1873
[45]   Two-Component Signal Transduction Systems, Environmental Signals, and Virulence [J].
E. Calva ;
R. Oropeza .
Microbial Ecology, 2006, 51 :166-176
[46]   Two-component circuitry in Arabidopsis cytokinin signal transduction. [J].
Hwang, I ;
Sheen, J .
DEVELOPMENTAL BIOLOGY, 2002, 247 (02) :484-484
[47]   Two-component signal transduction systems: the adapt and survive response [J].
Cheung, Jackie K. ;
Rood, Julian I. .
MICROBIOLOGY AUSTRALIA, 2006, 27 (03) :101-104
[48]   An essential two-component signal transduction system in Mycobacterium tuberculosis [J].
Zahrt, TC ;
Deretic, V .
JOURNAL OF BACTERIOLOGY, 2000, 182 (13) :3832-3838
[49]   Hysteretic and graded responses in bacterial two-component signal transduction [J].
Igoshin, Oleg A. ;
Alves, Rui ;
Savageau, Michael A. .
MOLECULAR MICROBIOLOGY, 2008, 68 (05) :1196-1215
[50]   Roles of Two-Component Signal Transduction Systems in Shigella Virulence [J].
Pasqua, Martina ;
Coluccia, Marco ;
Eguchi, Yoko ;
Okajima, Toshihide ;
Grossi, Milena ;
Prosseda, Gianni ;
Utsumi, Ryutaro ;
Colonna, Bianca .
BIOMOLECULES, 2022, 12 (09)