Inhibitors targeting two-component signal transduction

被引:0
|
作者
Watanabe, Takafumi [1 ]
Okada, Ario [1 ]
Gotoh, Yasuhiro [1 ]
Utsumi, Ryutaro [1 ]
机构
[1] Kinki Univ, Grad Sch Agr, Dept Biosci, Nara 6318505, Japan
来源
BACTERIAL SIGNAL TRANSDUCTION: NETWORKS AND DRUG TARGETS | 2008年 / 631卷
关键词
D O I
暂无
中图分类号
R-3 [医学研究方法]; R3 [基础医学];
学科分类号
1001 ;
摘要
A two-component signal transduction system (TCS) is an attractive target for antibacterial agents. In this chapter, we review the TCS inhibitors developed during the past decade and introduce novel drug discovery systems to isolate the inhibitors of the YycG/YycF system, an essential TCS for bacterial growth, in an effort to develop a new class of antibacterial agents.
引用
收藏
页码:229 / 236
页数:8
相关论文
共 50 条
  • [21] Two-component circuitry in Arabidopsis cytokinin signal transduction
    Hwang, I
    Sheen, J
    NATURE, 2001, 413 (6854) : 383 - 389
  • [22] Rewiring two-component signal transduction with small RNAs
    Goepel, Yvonne
    Goerke, Boris
    CURRENT OPINION IN MICROBIOLOGY, 2012, 15 (02) : 132 - 139
  • [23] Rewiring the specificity of two-component signal transduction systems
    Skerker, Jeffrey M.
    Perchuk, Barrett S.
    Siryaporn, Albert
    Lubin, Emma A.
    Ashenberg, Orr
    Goulian, Mark
    Laub, Michael T.
    CELL, 2008, 133 (06) : 1043 - 1054
  • [24] Receptor domains of two-component signal transduction systems
    Perry, Julie
    Koteva, Kalinka
    Wright, Gerard
    MOLECULAR BIOSYSTEMS, 2011, 7 (05) : 1388 - 1398
  • [25] Two-component signal transduction in human fungal pathogens
    Kruppa, M
    Calderone, R
    FEMS YEAST RESEARCH, 2006, 6 (02) : 149 - 159
  • [26] Two-component signal transduction systems in oral bacteria
    Mattos-Graner, Renata O.
    Duncan, Margaret J.
    JOURNAL OF ORAL MICROBIOLOGY, 2017, 9
  • [27] Structural basis of the signal transduction in the two-component system
    Yamada, Seiji
    Shiro, Yoshitsugu
    BACTERIAL SIGNAL TRANSDUCTION: NETWORKS AND DRUG TARGETS, 2008, 631 : 22 - 39
  • [28] Unusual two-component signal transduction pathways in the actinobacteria
    Hutchings, Matthew I.
    ADVANCES IN APPLIED MICROBIOLOGY, VOL 61, 2007, 61 : 1 - 26
  • [29] Histidine kinases and two-component signal transduction systems
    Pirrung, MC
    CHEMISTRY & BIOLOGY, 1999, 6 (06): : R167 - R175
  • [30] Signal integration by the two-component signal transduction response regulator CpxR
    Wolfe, Alan J.
    Parikh, Niyati
    Lima, Bruno P.
    Zemaitaitis, Bozena
    JOURNAL OF BACTERIOLOGY, 2008, 190 (07) : 2314 - 2322