Inhibitors targeting two-component signal transduction
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作者:
Watanabe, Takafumi
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机构:
Kinki Univ, Grad Sch Agr, Dept Biosci, Nara 6318505, JapanKinki Univ, Grad Sch Agr, Dept Biosci, Nara 6318505, Japan
Watanabe, Takafumi
[1
]
Okada, Ario
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机构:
Kinki Univ, Grad Sch Agr, Dept Biosci, Nara 6318505, JapanKinki Univ, Grad Sch Agr, Dept Biosci, Nara 6318505, Japan
Okada, Ario
[1
]
Gotoh, Yasuhiro
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机构:
Kinki Univ, Grad Sch Agr, Dept Biosci, Nara 6318505, JapanKinki Univ, Grad Sch Agr, Dept Biosci, Nara 6318505, Japan
Gotoh, Yasuhiro
[1
]
Utsumi, Ryutaro
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机构:
Kinki Univ, Grad Sch Agr, Dept Biosci, Nara 6318505, JapanKinki Univ, Grad Sch Agr, Dept Biosci, Nara 6318505, Japan
Utsumi, Ryutaro
[1
]
机构:
[1] Kinki Univ, Grad Sch Agr, Dept Biosci, Nara 6318505, Japan
来源:
BACTERIAL SIGNAL TRANSDUCTION: NETWORKS AND DRUG TARGETS
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2008年
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631卷
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暂无
中图分类号:
R-3 [医学研究方法];
R3 [基础医学];
学科分类号:
1001 ;
摘要:
A two-component signal transduction system (TCS) is an attractive target for antibacterial agents. In this chapter, we review the TCS inhibitors developed during the past decade and introduce novel drug discovery systems to isolate the inhibitors of the YycG/YycF system, an essential TCS for bacterial growth, in an effort to develop a new class of antibacterial agents.
机构:
Univ Med & Dent New Jersey, Robert Wood Johnson Med Sch, Ctr Adv Biotechnol & Med, Piscataway, NJ 08854 USAUniv Med & Dent New Jersey, Robert Wood Johnson Med Sch, Ctr Adv Biotechnol & Med, Piscataway, NJ 08854 USA
Stock, AM
Robinson, VL
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机构:Univ Med & Dent New Jersey, Robert Wood Johnson Med Sch, Ctr Adv Biotechnol & Med, Piscataway, NJ 08854 USA
Robinson, VL
Goudreau, PN
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机构:Univ Med & Dent New Jersey, Robert Wood Johnson Med Sch, Ctr Adv Biotechnol & Med, Piscataway, NJ 08854 USA
机构:
Scripps Res Inst, Dept Mol & Expt Med, Div Cellular Biol, La Jolla, CA 92037 USAScripps Res Inst, Dept Mol & Expt Med, Div Cellular Biol, La Jolla, CA 92037 USA
机构:
Scripps Res Inst, Dept Mol & Expt Med, Div Cellular Biol, La Jolla, CA 92037 USAScripps Res Inst, Dept Mol & Expt Med, Div Cellular Biol, La Jolla, CA 92037 USA
Stephenson, K
Yamaguchi, Y
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机构:
Scripps Res Inst, Dept Mol & Expt Med, Div Cellular Biol, La Jolla, CA 92037 USAScripps Res Inst, Dept Mol & Expt Med, Div Cellular Biol, La Jolla, CA 92037 USA
Yamaguchi, Y
Hoch, JA
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机构:
Scripps Res Inst, Dept Mol & Expt Med, Div Cellular Biol, La Jolla, CA 92037 USAScripps Res Inst, Dept Mol & Expt Med, Div Cellular Biol, La Jolla, CA 92037 USA
机构:
MIT, Computat & Syst Biol Initiat, Cambridge, MA 02139 USA
MIT, Dept Biol, Cambridge, MA 02139 USAMIT, Computat & Syst Biol Initiat, Cambridge, MA 02139 USA
Podgornaia, Anna I.
Laub, Michael T.
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机构:
MIT, Dept Biol, Cambridge, MA 02139 USA
MIT, Howard Hughes Med Inst, Cambridge, MA 02139 USAMIT, Computat & Syst Biol Initiat, Cambridge, MA 02139 USA