Relationships between CYP11B2-344C/T gene polymorphism and coronary artery disease: a meta-analysis

Objective and Background: The CYP11B2 gene has been suggested to play an important role in the pathogenesis of coronary artery disease (CAD). However, the results have been inconsistent. In this study, we performed a meta-analysis to clarify the association of the CYP11B2 -344C/T variant with CAD. Methods: A literature search of PubMed, Embase, Web of Science, CNKI and WanFang databases was conducted on articles published. The odds ratios with 95% confidence intervals were calculated. Heterogeneity analyses were performed using Q statistic. Tests for publication bias were also performed and biased studies should be removed from subsequent analyses. Results: A total of 7 case-control studies with a total of 2905 CAD patients and 5543 controls were included. There was no statistical evidence of association between CYP11B2 -344C/T polymorphism and CAD in all genetic models (allele model: OR 1.03, 95% CI 0.95-1.10, P = 0.49; dominant model: OR 1.13, 95% CI 0.77-1.66, P=0.54; recessive model: OR 1.02, 95% CI 0.92-1.14, P = 0.69; additive model: OR 1.03, 95% CI 0.89-1.21, P = 0.68, respectively). The pooled ORs were not substantially altered after the exclusion of one study in the control group that deviated from Hardy-Weinberg equilibrium. Conclusion: The present meta-analysis suggested that CYP11B2 -344C/T polymorphism was not contributed to CAD.