Cytochalasans from the Endophytic Fungus Xylaria cf. curta with Resistance Reversal Activity against Fluconazole-Resistant Candida albicans

被引：51

作者：

Wang, Wen-Xuan ^{[1
]}

Lei, Xinxiang ^{[1
]}

Ai, Hong-Lian ^{[1
]}

Bai, Xue ^{[2
]}

Li, Jing ^{[1
]}

He, Juan ^{[1
]}

Li, Zheng-Hui ^{[1
]}

Zheng, Yong-Sheng ^{[1
]}

Feng, Tao ^{[1
]}

Liu, Ji-Kai ^{[1
]}

机构：

[1] South Cent Univ Nationalities, Sch Pharmaceut Sci, Wuhan 430074, Hubei, Peoples R China

[2] Chinese Acad Sci, Kunming Inst Bot, Kunming 650204, Yunnan, Peoples R China

来源：

ORGANIC LETTERS | 2019年 / 21卷 / 04期

基金：

中国国家自然科学基金;

关键词：

STRUCTURE ELUCIDATION; FRUITING BODIES;

D O I：

10.1021/acs.orglett.9b00015

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Curtachalasins C-E (1-3), which have an unprecedent bridged 6/6/6/6 ring system, were identified from the endophytic fungus Xylaria cf. curta. Residual dipolar coupling analyses associating with density functional theory calculations were utilized to determine the relative configuration of noncrystallizable compound 2. The absolute configurations of 1-3 were determined by X-ray diffraction and electronic circular dichroism calculations. Remarkably, curtachalasin C (1) showed significant resistance reversal activity against fluconazole-resistant Candida albicans.

引用

页码：1108 / 1111

页数：4