Cancer of the esophagus and asbestos exposure

被引：12

作者：

Clin, Benedicte ^{[1
,2
,3
]}

Thaon, Isabelle ^{[4
,5
]}

Boulanger, Mathilde ^{[1
,2
,3
]}

Brochard, Patrick ^{[6
,7
,8
]}

Chamming's, Soizick ^{[9
]}

Gislard, Antoine ^{[10
]}

lacourt, AuDe ^{[6
,7
,8
]}

Luc, Amandine ^{[4
,5
]}

Ogier, Guy ^{[11
]}

Paris, Christophe ^{[4
,5
]}

Pairon, Jean-Claude ^{[12
,13
,14
]}

机构：

[1] INSERM U1086 ANTICIPE, Caen, France

[2] CHU Caen, Serv Sante Travail & Pathol Profess, Caen, France

[3] Univ Caen Normandie, Caen, France

[4] EA7298 INGRES, Nancy, France

[5] CHRU Nancy, Nancy, France

[6] Univ Bordeaux, EPICENE, INSERM U1219, Bordeaux Populat Hlth, Bordeaux, France

[7] Univ Bordeaux, ISPED, INSERM U1219, Bordeaux Populat Hlth, Bordeaux, France

[8] CHU Bordeaux, Bordeaux, France

[9] Inst Interuniv Med Travail Paris Ile France, Creteil, France

[10] CHU Rouen, Serv Malad Profess, Rouen, France

[11] ERSM Rhone Alpes, Reg Secur Insurance, Lyon, France

[12] Ctr Hosp Intercommunal Creteil, Serv Pneumol & Pathol Profess, DHU A TVB, Creteil, France

[13] Univ Paris Est Creteil, Inst Sante Travail Paris Est, Fac Med, Creteil, France

[14] INSERM U955, Equipe 4, Creteil, France

来源：

AMERICAN JOURNAL OF INDUSTRIAL MEDICINE | 2017年 / 60卷 / 11期

关键词：

asbestos; cancer; esophagus; incidence; mortality; occupational exposure; DIGESTIVE CANCERS; MORTALITY; COHORT; OCCUPATION; WORKERS; RISK;

D O I：

10.1002/ajim.22769

中图分类号：

R1 [预防医学、卫生学];

学科分类号：

1004 ; 120402 ;

摘要：

Background: Our study aimed at analyzing incidence and mortality from esophageal cancer within a cohort of workers with previous occupational asbestos exposure (ARDCo Program). Methods: A 10-year follow-up study was conducted in the 14 515 male subjects included in this program between October 2003 and December 2005. Follow-up began when exposure stopped. Asbestos exposure was analyzed by industrial hygienists using data from a standardized questionnaire. The Cox model was used, with age as the time axis variable adjusted for smoking, time since first exposure (TSFE) and cumulative exposure index (CEI) of exposure to asbestos. Results: We reported a significant dose-response relationship between CEI of exposure to asbestos and esophageal cancer, in both incidence (hazard ratio [HR] 1.26, 95% confidence interval [CI] 1.00-1.58), and mortality (HR 1.40, [95% CI 1.12-1.75]). Conclusions: This large-scale study suggests the existence of a relationship between asbestos exposure and cancer of the esophagus

引用

页码：968 / 975

页数：8

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