Xenotransplantation and interspecies organogenesis: current status and issues

被引：11
作者：
Kano, Mayuko [1 ]
Mizutani, Eiji [1 ,2 ]
Homma, Shota [3 ]
Masaki, Hideki [1 ]
Nakauchi, Hiromitsu [1 ,3 ]
机构：
[1] Tokyo Med & Dent Univ, Adv Res Inst, Stem Cell Therapy Lab, Tokyo, Japan
[2] Univ Tsukuba, Fac Med, Lab Stem Cell Therapy, Tsukuba, Japan
[3] Stanford Univ, Inst Stem Cell Biol & Regenerat Med, Sch Med, Stanford, CA 94305 USA
来源：
FRONTIERS IN ENDOCRINOLOGY | 2022年 / 13卷
基金：
日本学术振兴会;
关键词：
xenotransplantation; blastocyst complementation; pluripotent stem cells; chimera; type; 1; diabetes; pancreas; islet; N-GLYCOLYLNEURAMINIC ACID; PLURIPOTENT STEM-CELLS; ISLET XENOTRANSPLANTATION; BLASTOCYST COMPLEMENTATION; ENDOTHELIAL-CELLS; NUCLEAR TRANSFER; KNOCKOUT PIGS; IN-VIVO; PANCREAS; MOUSE;
D O I：
10.3389/fendo.2022.963282
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
Pancreas (and islet) transplantation is the only curative treatment for type 1 diabetes patients whose beta-cell functions have been abolished. However, the lack of donor organs has been the major hurdle to save a large number of patients. Therefore, transplantation of animal organs is expected to be an alternative method to solve the serious shortage of donor organs. More recently, a method to generate organs from pluripotent stem cells inside the body of other species has been developed. This interspecies organ generation using blastocyst complementation (BC) is expected to be the next-generation regenerative medicine. Here, we describe the recent advances and future prospects for these two approaches.
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页数：8
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