Palladium-mediated fluorination of arylboronic acids

被引：217
|
作者：
Furuya, Takeru [1 ]
Kaiser, Hanns Martin [1 ]
Ritter, Tobias [1 ]
机构：
[1] Harvard Univ, Dept Chem & Chem Biol, Cambridge, MA 02138 USA
来源：
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2008年 / 47卷 / 32期
关键词：
boronic acids; fluorination; palladium; synthetic methods; tomography;
D O I：
10.1002/anie.200802164
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
(Chemical Equation Presented) Saving the best for last: Novel palladium complexes allow mild, two-step fluorination of aryl boronic acids (see scheme). The reaction is regiospecific, functional-group tolerant, has a broad substrate scope, and is ideally suited for the introduction of fluorine substituents at a late stage for aryl fluoride synthesis. © 2008 Wiley-VCH Verlag GmbH & Co. KGaA.
引用
收藏
页码：5993 / 5996
页数：4
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