Palladium-mediated fluorination of arylboronic acids

被引：218

作者：

Furuya, Takeru ^{[1
]}

Kaiser, Hanns Martin ^{[1
]}

Ritter, Tobias ^{[1
]}

机构：

[1] Harvard Univ, Dept Chem & Chem Biol, Cambridge, MA 02138 USA

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2008年 / 47卷 / 32期

关键词：

boronic acids; fluorination; palladium; synthetic methods; tomography;

D O I：

10.1002/anie.200802164

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

(Chemical Equation Presented) Saving the best for last: Novel palladium complexes allow mild, two-step fluorination of aryl boronic acids (see scheme). The reaction is regiospecific, functional-group tolerant, has a broad substrate scope, and is ideally suited for the introduction of fluorine substituents at a late stage for aryl fluoride synthesis. © 2008 Wiley-VCH Verlag GmbH & Co. KGaA.

引用

页码：5993 / 5996

页数：4

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