NOD-Like Receptors: Guardians of Intestinal Mucosal Barriers

被引：48

作者：

Claes, Anne-Kathrin ^{[1
,2
,3
]}

Zhou, Jun Yu ^{[1
]}

Philpott, Dana J. ^{[1
]}

机构：

[1] Univ Toronto, Dept Immunol, Toronto, ON, Canada

[2] Res Ctr Borstel, Leibniz Ctr Med & Biosci, Div Models Inflammat, Borstel, Germany

[3] Univ Kiel, Inst Expt Med, Kiel, Germany

来源：

PHYSIOLOGY | 2015年 / 30卷 / 03期

基金：

加拿大健康研究院; 加拿大自然科学与工程研究理事会;

关键词：

NF-KAPPA-B; INNATE IMMUNE ACTIVATION; OLIGOMERIZATION DOMAIN 1; MURAMYL DIPEPTIDE; NLRP3; INFLAMMASOME; CROHNS-DISEASE; INSERTION/DELETION POLYMORPHISM; PATTERN-RECOGNITION; NEGATIVE REGULATION; NALP3;

D O I：

10.1152/physiol.00025.2014

中图分类号：

Q4 [生理学];

学科分类号：

071003 ;

摘要：

The NOD-like receptors (NLRs) are cytosolic pattern-recognition receptors, which are critically involved in mucosal immune defense. The association of the NLR, NOD2, with inflammatory bowel disease first pointed to the NLRs potential function as guardians of the intestinal barrier. Since then, several studies have emphasized the importance of NLRs in maintaining gut homeostasis and intestinal infections, and in shaping the microbiota. In this review, we will highlight the function of NLRs in intestinal inflammation.

引用

收藏

页码：241 / 250

页数：10

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