NIR-Triggered Sequentially Responsive Nanocarriers Amplified Cascade Synergistic Effect of Chemo-Photodynamic Therapy with Inspired Antitumor Immunity

被引：47

作者：

Jin, Feiyang ^{[1
]}

Qi, Jing ^{[1
]}

Zhu, Minxia ^{[1
]}

Liu, Di ^{[1
]}

You, Yuchan ^{[1
]}

Shu, Gaofeng ^{[2
]}

Du, Yan ^{[1
]}

Wang, Jun ^{[1
]}

Yu, Hui ^{[1
]}

Sun, Mingchen ^{[1
]}

Xu, Xiaoling ^{[1
]}

Shen, Qiying ^{[1
]}

Ying, Xiaoying ^{[1
]}

Ji, Jiansong ^{[2
]}

Du, Yongzhong ^{[1
]}

机构：

[1] Zhejiang Univ, Coll Pharmaceut Sci, Inst Pharmaceut, Hangzhou 310058, Peoples R China

[2] Zhejiang Univ, Lishui Hosp, Dept Radiol, Lishui 323000, Peoples R China

来源：

ACS APPLIED MATERIALS & INTERFACES | 2020年 / 12卷 / 29期

关键词：

chemo-photodynamic therapy; upconversion nanoparticles; ROS-responsive micelles; immunogenic cell death; tumor metastasis; IMMUNOGENIC CELL-DEATH; UP-CONVERSION NANOPARTICLES; SIALIC-ACID; UPCONVERTING NANOPARTICLES; CONJUGATED POLYELECTROLYTE; DRUG-DELIVERY; CANCER; SYSTEM; LIGHT; COMBINATION;

D O I：

10.1021/acsami.0c07503

中图分类号：

TB3 [工程材料学];

学科分类号：

0805 ; 080502 ;

摘要：

A desirable cancer therapeutic strategy is supposed to have effective ability to not only exert maximum anticancer ability but also inspire antitumor immunity for preventing tumor relapse and metastasis. During this research, multifunctional upconversion nanoparticles (UCNPs) coated by ROS-responsive micelles are prepared for tumor targeting and near-infrared (NIR)-triggered photodynamic therapy (PDT)-combined synergistic effect of chemotherapy. Moreover, both PDT and chemotherapy agents could activate antitumor immunity via inducing immunogenic cell death with CD8(+) and CD4(+)T cells infiltrating in tumors. Through the experiments, intravenous administration of multifunctional nanocarriers with noninvasive NIR irradiation destroys the orthotopic tumors and efficiently suppresses lung metastasis in a metastatic triple-negative breast cancer model by cascade-amplifying chemo-PDT and systemic antitumor immunity. In conclusion, this study provides prospective chemo-PDT with inspired antitumor immunity for metastatic cancer treatment.

引用

页码：32372 / 32387

页数：16

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