SERIES "MATRIX METALLOPROTEINASES IN LUNG HEALTH AND DISEASE" Metalloproteinases in idiopathic pulmonary fibrosis

被引：122

作者：

Dancer, R. C. A. ^{[1
]}

Wood, A. M. ^{[1
]}

Thickett, D. R. ^{[1
]}

机构：

[1] Univ Birmingham, Sch Clin & Expt Med, Birmingham B15 2TT, W Midlands, England

来源：

EUROPEAN RESPIRATORY JOURNAL | 2011年 / 38卷 / 06期

关键词：

Idiopathic pulmonary fibrosis; matrix metalloproteinase; GENE-EXPRESSION PROFILES; TISSUE INHIBITOR; MESENCHYMAL TRANSITION; GELATINASE B; PIRFENIDONE; MATRIX-METALLOPROTEINASE-9; INJURY; OVEREXPRESSION; LOCALIZATION; PERMEABILITY;

D O I：

10.1183/09031936.00024711

中图分类号：

R56 [呼吸系及胸部疾病];

学科分类号：

摘要：

In this article, we outline the current state of knowledge about the balance between collagen production and degradation in idiopathic pulmonary fibrosis (IPF). The dysregulated action of metalloproteinases implicated in IPF may play a central role in IPF pathogenesis. Inhibiting metalloproteinases in IPF may, therefore, have therapeutic potential, but our knowledge of their pathophysiological role is held back by limited animal models and the lack of specific inhibitors.

引用

页码：1461 / 1467

页数：7

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