SERIES "MATRIX METALLOPROTEINASES IN LUNG HEALTH AND DISEASE" Metalloproteinases in idiopathic pulmonary fibrosis

被引：116

作者：

Dancer, R. C. A. ^{[1
]}

Wood, A. M. ^{[1
]}

Thickett, D. R. ^{[1
]}

机构：

[1] Univ Birmingham, Sch Clin & Expt Med, Birmingham B15 2TT, W Midlands, England

来源：

EUROPEAN RESPIRATORY JOURNAL | 2011年 / 38卷 / 06期

关键词：

Idiopathic pulmonary fibrosis; matrix metalloproteinase; GENE-EXPRESSION PROFILES; TISSUE INHIBITOR; MESENCHYMAL TRANSITION; GELATINASE B; PIRFENIDONE; MATRIX-METALLOPROTEINASE-9; INJURY; OVEREXPRESSION; LOCALIZATION; PERMEABILITY;

D O I：

10.1183/09031936.00024711

中图分类号：

R56 [呼吸系及胸部疾病];

学科分类号：

摘要：

In this article, we outline the current state of knowledge about the balance between collagen production and degradation in idiopathic pulmonary fibrosis (IPF). The dysregulated action of metalloproteinases implicated in IPF may play a central role in IPF pathogenesis. Inhibiting metalloproteinases in IPF may, therefore, have therapeutic potential, but our knowledge of their pathophysiological role is held back by limited animal models and the lack of specific inhibitors.

引用

页码：1461 / 1467

页数：7

共 61 条

[1] Fibrocytes are a potential source of lung fibroblasts in idiopathic pulmonary fibrosis
Andersson-Sjoland, Annika
de Alba, Carolina Garcia
Nihlberg, Kristian
Becerril, Carina
Ramirez, Remedios
Pardo, Annie
Westergren-Thorsson, Gunilla
Selman, Moises
[J]. INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY, 2008, 40 (10) : 2129 - 2140
[2] Matrix metalloproteinase-9 in lung remodeling
Atkinson, JJ
Senior, RM
[J]. AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY, 2003, 28 (01) : 12 - 24
[3] Gelatinase B is required for alveolar bronchiolization after intratracheal bleomycin
Betsuyaku, T
Fukuda, Y
Parks, WC
Shipley, JM
Senior, RM
[J]. AMERICAN JOURNAL OF PATHOLOGY, 2000, 157 (02) : 525 - 535
[4] The role of long-term doxycycline in patients of idiopathic pulmonaryfibrosis: The results of an open prospective trial
Bhattacharyya, Parthasarathi
Nag, Saikat
Bardhan, Sujan
Acharya, Dipabali
Paul, Rantu
Dey, Rana
Ghosh, Malabika
Dey, Ratna
Saha, Indranil
[J]. LUNG INDIA, 2009, 26 (03) : 81 - 85
[5] Overexpression of MMP9 in macrophages attenuates pulmonary fibrosis induced by bleomycin
Cabrera, Sandra
Gaxiola, Miguel
Luis Arreola, Jose
Ramirez, Remedios
Jara, Paul
D'Armiento, Jeanine
Richards, Thomas
Selman, Moises
Pardo, Annie
[J]. INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY, 2007, 39 (12) : 2324 - 2338
[6] MMP-1 polymorphisms and the risk of idiopathic pulmonary fibrosis
Checa, Marco
Ruiz, Victor
Montano, Martha
Velazquez-Cruz, Rafael
Selman, Moises
Pardo, Annie
[J]. HUMAN GENETICS, 2008, 124 (05) : 465 - 472
[7] The role of matrix metalloproteinase-9 and tissue inhibitor of metalloproteinase-1 in cryptogenic organizing pneumonia
Choi, KH
Lee, HB
Jeong, MY
Rhee, YK
Chung, MJ
Kwak, YG
Lee, YC
[J]. CHEST, 2002, 121 (05) : 1478 - 1485
[8] Fibroblast foci are not discrete sites of lung injury or repair - The fibroblast reticulum
Cool, Carlyne D.
Groshong, Steve D.
Rai, Pradeep R.
Henson, Peter M.
Stewart, J. Scott
Brown, Kevin K.
[J]. AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 2006, 174 (06) : 654 - 658
[9] Modulation of airway remodeling-associated mediators by the antifibrotic compound, pirfenidone, and the matrix metalloproteinase inhibitor, batimastat, during acute lung injury in mice
Corbel, M
Lanchou, JM
Germain, N
Malledant, Y
Boichot, E
Lagente, V
[J]. EUROPEAN JOURNAL OF PHARMACOLOGY, 2001, 426 (1-2) : 113 - 121
[10] Pigment epithelium - derived factor in idiopathic pulmonary fibrosis - A role in aberrant angiogenesis
Cosgrove, GP
Brown, KK
Schiemann, WP
Serls, AE
Parr, JE
Geraci, MW
Schwarz, MI
Cool, CD
Worthen, GS
[J]. AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 2004, 170 (03) : 242 - 251

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