Targeted inhibition by RNA interference-mediated gene silencing of mannan-binding lectin-associated serine protease (MASP)-1/3 expression attenuates collagen antibody-induced arthritis (CAIA)

被引：0
|
作者：
Banda, Nirmal K. [1 ]
Acharya, Sumitra [1 ]
Scheinman, Robert I. [2 ]
Mehta, Gaurav [1 ,3 ]
Takahashi, Minoru [3 ]
Mortensen, Simon [4 ]
Thiel, Steffen [4 ]
Sekine, Hideharu [3 ]
Fujita, Teizo [3 ]
Holers, V. Michael [1 ]
机构：
[1] Univ Colorado, Dept Med, Div Rheumatol, Anschutz Med Campus, Aurora, CO USA
[2] Univ Colorado, Sch Pharm, Anschutz Med Campus, Aurora, CO USA
[3] Fukushima Med Univ, Dept Immunol, Fukushima, Japan
[4] Univ Aarhus, Dept Biomed, DK-8000 Aarhus C, Denmark
来源：
IMMUNOBIOLOGY | 2016年 / 221卷 / 10期
关键词：
D O I：
10.1016/j.imbio.2016.06.017
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
2
引用
收藏
页码：1131 / 1132
页数：2
相关论文
共 17 条
  • [1] Mannan-Binding Lectin-Associated Serine Protease 1/3 Cleavage of Pro-Factor D into Factor D In Vivo and Attenuation of Collagen Antibody-Induced Arthritis through Their Targeted Inhibition by RNA Interference-Mediated Gene Silencing
    Banda, Nirmal K.
    Acharya, Sumitra
    Scheinman, Robert I.
    Mehta, Gaurav
    Coulombe, Marilyne
    Takahashi, Minoru
    Sekine, Hideharu
    Thiel, Steffen
    Fujita, Teizo
    Holers, V. Michael
    JOURNAL OF IMMUNOLOGY, 2016, 197 (09): : 3680 - 3694
  • [2] siRNA-mediated targeting of hepatocyte mannan-binding lectin-associated serine protease-3 for the treatment of murine collagen-antibody-inducsed arthritis (CAIA), a model for human rheumatoid arthritis
    Banda, Nirmal K.
    Desai, Dhruv
    Casterano, Adam
    Scheinman, Robert I.
    Acharya, Sumitra
    Sekine, Hideharu
    Fujita, Teizo
    Hansen, Annette G.
    Thiel, Steffen
    Borodovsky, Anna
    Holers, V. Michael
    MOLECULAR IMMUNOLOGY, 2017, 89 : 161 - 161
  • [3] Characterization of recombinant mannan-binding lectin-associated serine protease (MASP)-3 suggests an activation mechanism different from that of MASP-1 and MASP-2
    Zundel, S
    Cseh, S
    Lacroix, M
    Dahl, MR
    Matsushita, M
    Andrieu, JP
    Schwaeble, WJ
    Jensenius, JC
    Fujita, T
    Arlaud, GJ
    Thielens, NM
    JOURNAL OF IMMUNOLOGY, 2004, 172 (07): : 4342 - 4350
  • [4] Mannan-Binding Lectin-Associated Serine Protease (MASP)-1 Is Crucial for Lectin Pathway Activation in Human Serum, whereas neither MASP-1 nor MASP-3 Is Required for Alternative Pathway Function
    Degn, Soren E.
    Jensen, Lisbeth
    Hansen, Annette G.
    Duman, Duygu
    Tekin, Mustafa
    Jensenius, Jens C.
    Thiel, Steffen
    JOURNAL OF IMMUNOLOGY, 2012, 189 (08): : 3957 - 3969
  • [5] Effects on arthritis of RNAi-mediated targeting of liver expression of mannan-binding lectin associated serine protease 1 and 2
    Holers, V. Michael
    Desai, Dhruv
    Scheinman, Robert I.
    Ramirez, Joseline R.
    Khan, Numair
    Hansen, Annette G.
    Thiel, Steffen
    Borodovsky, Anna
    Banda, Nirmal K.
    MOLECULAR IMMUNOLOGY, 2018, 102 : 133 - 133
  • [6] C3 dysregulation due to factor H deficiency is mannan-binding lectin-associated serine proteases (MASP)-1 and MASP-3 independent in vivo
    Ruseva, M. M.
    Takahashi, M.
    Fujita, T.
    Pickering, M. C.
    CLINICAL AND EXPERIMENTAL IMMUNOLOGY, 2014, 176 (01): : 84 - 92
  • [7] Response to Comment on "Mannan-Binding Lectin-Associated Serine Protease (MASP)-1 Is Crucial for Lectin Pathway Activation in Human Serum, whereas neither MASP-1 nor MASP-3 Is Required for Alternative Pathway Function"
    Degn, Soren E.
    Jensenius, Jens C.
    Thiel, Steffen
    JOURNAL OF IMMUNOLOGY, 2013, 190 (06): : 2477 - 2478
  • [8] Mannan-binding lectin-associated serine protease-1 (MASP-1) mediates immune responses against Aeromonas hydrophila in vitro and in vivo in grass carp
    Dang, Yun-Fei
    Shen, Yu-Bang
    Xu, Xiao-Yan
    Wang, Shen-Tong
    Meng, Xin-Zhan
    Li, Li-Sen
    Zhang, Meng
    Hu, Mo-Yan
    Lv, Li-Qun
    Wang, Rong-Quan
    Li, Jia-Le
    FISH & SHELLFISH IMMUNOLOGY, 2017, 66 : 93 - 102
  • [9] Monospecific Inhibitors Show That Both Mannan-binding Lectin-associated Serine Protease-1 (MASP-1) and-2 Are Essential for Lectin Pathway Activation and Reveal Structural Plasticity of MASP-2
    Heja, David
    Harmat, Veronika
    Fodor, Krisztian
    Wilmanns, Matthias
    Dobo, Jozsef
    Kekesi, Katalin A.
    Zavodszky, Peter
    Gal, Peter
    Pal, Gabor
    JOURNAL OF BIOLOGICAL CHEMISTRY, 2012, 287 (24) : 20290 - 20300
  • [10] Essential Role of Complement Mannose-Binding Lectin-Associated Serine Proteases-1/3 in the Murine Collagen Antibody-Induced Model of Inflammatory Arthritis
    Banda, Nirmal K.
    Takahashi, Minoru
    Levitt, Brandt
    Glogowska, Magdalena
    Nicholas, Jessica
    Takahashi, Kazue
    Stahl, Gregory L.
    Fujita, Teizo
    Arend, William P.
    Holers, V. Michael
    JOURNAL OF IMMUNOLOGY, 2010, 185 (09): : 5598 - 5606
12