Complete Resolution of Sickle Cell Chronic Pain With High Dose Vitamin D Therapy: A Case Report and Review of the Literature

被引：19

作者：

Osunkwo, Ifeyinwa ^{[1
,2
]}

机构：

[1] Emory Univ, Sch Med, Dept Pediat, Atlanta, GA 30322 USA

[2] Childrens Healthcare Atlanta, Aflac Ctr Canc & Blood Disorders Serv, Comprehens Sickle Cell Program, Atlanta, GA USA

来源：

JOURNAL OF PEDIATRIC HEMATOLOGY ONCOLOGY | 2011年 / 33卷 / 07期

关键词：

sickle cell disease; vitamin D deficiency; chronic pain; D DEFICIENCY; CHILDREN; DISEASE; PREVALENCE; ADULTS;

D O I：

10.1097/MPH.0b013e31821ed3ea

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

With age, individuals with sickle cell disease (SCD) experience daily chronic pain. Vitamin D deficiency (VDD) can result in chronic pain, osteoporosis, fractures, and muscle weakness. Several studies report a high prevalence of VDD in SCD; however, the clinical correlates have not been well described. We describe a case of SCD chronic pain associated with profound VDD, osteoporosis, and osteonecrosis. Treatment with high-dose vitamin D resulted in complete resolution of chronic pain symptoms and improvement in bone density. Randomized studies of vitamin D in SCD may help elucidate its role in the management of chronic pain and bone disease.

引用

页码：549 / 551

页数：3

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