Role of Antithrombin III and Tissue Factor Pathway in the Pathogenesis of Sepsis

被引：46
作者：
Sungurlu, Sarah [1 ,2 ]
Kuppy, Jessica [1 ,2 ]
Balk, Robert A. [1 ]
机构：
[1] Rush Med Coll, Div Pulm Crit Care & Sleep Med, 1725 West Harrison St,Suite 054, Chicago, IL 60612 USA
[2] Rush Univ, Med Ctr, 1725 West Harrison St,Suite 054, Chicago, IL 60612 USA
来源：
CRITICAL CARE CLINICS | 2020年 / 36卷 / 02期
关键词：
Antithrombin; Tissue factor; Sepsis; Coagulopathy; Multiple organ failure; DISSEMINATED INTRAVASCULAR COAGULATION; MULTIPLE ORGAN FAILURE; ACTIVATED PROTEIN-C; SEPTIC SHOCK; DOUBLE-BLIND; EFFICACY; SAFETY; INHIBITOR; MORTALITY; TRIAL;
D O I：
10.1016/j.ccc.2019.12.002
中图分类号：
R4 [临床医学];
学科分类号：
1002 ; 100602 ;
摘要：
The pathobiology of the septic process includes a complex interrelationship between inflammation and the coagulations system. Antithrombin (AT) and tissue factor are important components of the coagulation system and have potential roles in the production and amplification of sepsis. Sepsis is associated with a decrease in AT levels, and low levels are also associated with the development of multiple organ failure and death. Treatment strategies incorporating AT replacement therapy in sepsis and septic shock have not resulted in an improvement in survival or reversal of disseminated intravascular coagulation.
引用
收藏
页码：255 / 265
页数：11
相关论文
共 36 条
  • [1] Efficacy and safety of tifacogin (recombinant tissue factor pathway inhibitor) in severe sepsis -: A randomized controlled trial
    Abraham, E
    Reinhart, K
    Opal, S
    Demeyer, I
    Doig, C
    Rodriguez, AL
    Beale, R
    Svoboda, P
    Laterre, PF
    Simon, S
    Light, B
    Spapen, H
    Stone, J
    Seibert, A
    Peckelsen, C
    De Deyne, C
    Postier, R
    Pettilä, V
    Sprung, CL
    Artigas, A
    Percell, SR
    Shu, V
    Zwingelstein, C
    Tobias, J
    Poole, L
    Stolzenbach, JC
    Creasey, AA
    [J]. JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 2003, 290 (02): : 238 - 247
  • [2] ABRAHAM E, 2000, CRIT CARE MED S, V28, pS3
  • [3] Mechanisms of sepsis-induced organ dysfunction
    Abraham, Edward
    Singer, Mervyn
    [J]. CRITICAL CARE MEDICINE, 2007, 35 (10) : 2408 - 2416
  • [4] Cost-effectiveness of drotrecogin alfa (activated) in the treatment of severe sepsis
    Angus, DC
    Linde-Zwirble, WT
    Clermont, G
    Ball, DE
    Basson, BR
    Ely, EW
    Laterre, PF
    Vincent, JL
    Bernard, G
    van Hout, B
    [J]. CRITICAL CARE MEDICINE, 2003, 31 (01) : 1 - 11
  • [5] An enhanced fibrinolysis prevents the development of multiple organ failure in disseminated intravascular coagulation in spite of much activation of blood coagulation
    Asakura, H
    Ontachi, Y
    Mizutani, T
    Kato, M
    Saito, M
    Kumabashiri, I
    Morishita, E
    Yamazaki, M
    Aoshima, K
    Nakao, S
    [J]. CRITICAL CARE MEDICINE, 2001, 29 (06) : 1164 - 1168
  • [6] Efficacy and safety of recombinant human activated protein C for severe sepsis.
    Bernard, GR
    Vincent, JL
    Laterre, P
    LaRosa, SP
    Dhainaut, JF
    Lopez-Rodriguez, A
    Steingrub, JS
    Garber, GE
    Helterbrand, JD
    Ely, EW
    Fisher, CJ
    [J]. NEW ENGLAND JOURNAL OF MEDICINE, 2001, 344 (10) : 699 - 709
  • [7] Tissue factor pathway inhibitor dose-dependently inhibits coagulation activation without influencing the fibrinolytic and cytokine response during human endotoxemia
    de Jonge, E
    Dekkers, PEP
    Creasey, AA
    Hack, CE
    Paulson, SK
    Karim, A
    Kesecioglu, J
    Levi, M
    van Deventer, SJH
    van der Poll, T
    [J]. BLOOD, 2000, 95 (04) : 1124 - 1129
  • [8] Evolving role of tissue factor and its pathway inhibitor
    Doshi, SN
    Marmur, JD
    [J]. CRITICAL CARE MEDICINE, 2002, 30 (05) : S241 - S250
  • [9] Antithrombin III in patients with severe sepsis - A randomized, placebo-controlled, double-blind multicenter trial plus a meta-analysis on all randomized, placebo-controlled, double-blind trials with antithrombin III in severe sepsis
    Eisele, B
    Lamy, M
    Thijs, LG
    Keinecke, HO
    Schuster, HP
    Matthias, FR
    Fourrier, F
    Heinrichs, H
    Delvos, U
    [J]. INTENSIVE CARE MEDICINE, 1998, 24 (07) : 663 - 672
  • [10] SEPTIC SHOCK, MULTIPLE ORGAN FAILURE, AND DISSEMINATED INTRAVASCULAR COAGULATION - COMPARED PATTERNS OF ANTITHROMBIN-III, PROTEIN-C, AND PROTEIN-S DEFICIENCIES
    FOURRIER, F
    CHOPIN, C
    GOUDEMAND, J
    HENDRYCX, S
    CARON, C
    RIME, A
    MAREY, A
    LESTAVEL, P
    [J]. CHEST, 1992, 101 (03) : 816 - 823
1234