Electro-oxidative Intermolecular Allylic C(sp3)-H Aminations

被引：22

作者：

Wang, Yulei ^{[1
,2
]}

Lin, Zhipeng ^{[1
,2
]}

Oliveira, Joao C. A. ^{[1
,2
]}

Ackermann, Lutz ^{[1
,2
]}

机构：

[1] Georg August Univ Gottingen, Inst Organ & Biomol Chem, D-37077 Gottingen, Germany

[2] Georg August Univ Gottingen, Wohler Res Inst Sustainable Chem WISCh, D-37077 Gottingen, Germany

来源：

JOURNAL OF ORGANIC CHEMISTRY | 2021年 / 86卷 / 22期

关键词：

C-H FUNCTIONALIZATION; ALCOHOLS; ELECTROCHEMISTRY; ELECTROSYNTHESIS; STRATEGIES; AMINES; BONDS; HYDROXYPHTHALIMIDE; ALLYLATION; ANILINES;

D O I：

10.1021/acs.joc.1c00682

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The oxidative intermolecular nitrogenation of C(sp(3))-H bonds represents one of the most straightforward strategies to construct nitrogen-containing molecules. However, a sacrificial chemical oxidant is generally required. Herein, we describe electrochemical oxidative intermolecular allylic C(sp(3))-H aminations in an undivided cell by electric current. The cross-dehydrogenative amination proceeded efficiently with ample scope under metal-and chemical oxidant-free reaction conditions, giving molecular H-2 as the only byproduct.

引用

页码：15935 / 15945

页数：11

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