The crucial role of prolactin-lactogenic hormone in Covid-19

被引:37
作者
Al-Kuraishy, Hayder M. [1 ]
Al-Gareeb, Ali, I [1 ]
Butnariu, Monica [2 ]
Batiha, Gaber El-Saber [3 ]
机构
[1] Al Mustansiriyah Univ, Coll Med, POB 14132, Baghdad, Iraq
[2] Banats Univ Agr Sci & Vet Med King Michael I Roma, Chem & Biochem Discipline, Calea Aradului 119, Timis 300645, Romania
[3] Damanhour Univ, Fac Vet Med, Dept Pharmacol & Therapeut, Damanhour 22511, Albeheira, Egypt
关键词
Prolactin; Covid-19; Anti-inflammatory effects; Pro-inflammatory cytokines; STRESS-INDUCED DYSFUNCTION; REGULATORY T-CELLS; GROWTH-HORMONE; EXPRESSION; RECEPTOR; PREDICTORS; CYTOKINES; RELEASE;
D O I
10.1007/s11010-022-04381-9
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
Prolactin (PRL) is a peptide hormone secreted from anterior pituitary involved in milk production in the females and regulation of sex drive in both sexes. PRL has pro-inflammatory and anti-inflammatory functions. High PRL serum level or hyperprolactinemia is associated with different viral infections. In coronavirus disease 2019 (Covid-19), which caused by positive-sense single-strand RNA virus known as severe acute respiratory distress syndrome coronavirus type 2 (SARS-CoV-2), PRL serum level is increased. PRL in Covid-19 may exacerbate the underlying inflammatory status by induction release of pro-inflammatory cytokines. However, PRL through its anti-inflammatory effects may reduce the hyperinflammatory status in Covid-19. The underlying mechanism of increasing PRL in Covid-19 is poorly understood. Therefore, in this review we try to find the potential anti-inflammatory or pro-inflammatory role of PRL in Covid-19. As well, this review was aimed to discuss the underlying causes and mechanisms for Covid-19-induced hyperprolactinemia.
引用
收藏
页码:1381 / 1392
页数:12
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