The crucial role of prolactin-lactogenic hormone in Covid-19

被引：34
作者：
Al-Kuraishy, Hayder M. [1 ]
Al-Gareeb, Ali, I [1 ]
Butnariu, Monica [2 ]
Batiha, Gaber El-Saber [3 ]
机构：
[1] Al Mustansiriyah Univ, Coll Med, POB 14132, Baghdad, Iraq
[2] Banats Univ Agr Sci & Vet Med King Michael I Roma, Chem & Biochem Discipline, Calea Aradului 119, Timis 300645, Romania
[3] Damanhour Univ, Fac Vet Med, Dept Pharmacol & Therapeut, Damanhour 22511, Albeheira, Egypt
来源：
MOLECULAR AND CELLULAR BIOCHEMISTRY | 2022年 / 477卷 / 05期
关键词：
Prolactin; Covid-19; Anti-inflammatory effects; Pro-inflammatory cytokines; STRESS-INDUCED DYSFUNCTION; REGULATORY T-CELLS; GROWTH-HORMONE; EXPRESSION; RECEPTOR; PREDICTORS; CYTOKINES; RELEASE;
D O I：
10.1007/s11010-022-04381-9
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Prolactin (PRL) is a peptide hormone secreted from anterior pituitary involved in milk production in the females and regulation of sex drive in both sexes. PRL has pro-inflammatory and anti-inflammatory functions. High PRL serum level or hyperprolactinemia is associated with different viral infections. In coronavirus disease 2019 (Covid-19), which caused by positive-sense single-strand RNA virus known as severe acute respiratory distress syndrome coronavirus type 2 (SARS-CoV-2), PRL serum level is increased. PRL in Covid-19 may exacerbate the underlying inflammatory status by induction release of pro-inflammatory cytokines. However, PRL through its anti-inflammatory effects may reduce the hyperinflammatory status in Covid-19. The underlying mechanism of increasing PRL in Covid-19 is poorly understood. Therefore, in this review we try to find the potential anti-inflammatory or pro-inflammatory role of PRL in Covid-19. As well, this review was aimed to discuss the underlying causes and mechanisms for Covid-19-induced hyperprolactinemia.
引用
收藏
页码：1381 / 1392
页数：12
相关论文
共 102 条
[1]   Prolactin Receptor Isoforms as the Basis of Tissue-Specific Action of Prolactin in the Norm and Pathology [J].
Abramicheva, P. A. ;
Smirnova, O. V. .
BIOCHEMISTRY-MOSCOW, 2019, 84 (04) :329-345
[2]   Human gonadotropin-releasing hormone receptor-activated cellular functions and signaling pathways in extra-pituitary tissues and cancer cells (Review) [J].
Aguilar-Rojas, Arturo ;
Huerta-Reyes, Maira .
ONCOLOGY REPORTS, 2009, 22 (05) :981-990
[3]   ANGIOTENSIN-II RECEPTORS AND PROLACTIN-RELEASE IN PITUITARY LACTOTROPHS [J].
AGUILERA, G ;
HYDE, CL ;
CATT, KJ .
ENDOCRINOLOGY, 1982, 111 (04) :1045-1050
[4]   Renin-Angiotensin system and fibrinolytic pathway in COVID-19: One-way skepticism [J].
Al-Kuraishy, Hayder ;
Hussien, Nawar ;
Al-Naimi, Marwa ;
Al-Buhadily, Ali ;
Al-Gareeb, Ali ;
Lungnier, Claire .
BIOMEDICAL AND BIOTECHNOLOGY RESEARCH JOURNAL, 2020, 4 (05) :33-40
[5]   Acute kidney injury and COVID-19 [J].
Hayder M. Al-kuraishy ;
Ali I. Al-Gareeb .
The Egyptian Journal of Internal Medicine, 2021, 33 (1)
[6]   Arginine vasopressin and pathophysiology of COVID-19: An innovative perspective [J].
Al-kuraishy, Hayder M. ;
Al-Gareeb, Ali, I ;
Qusti, Safaa ;
Alshammari, Eida M. ;
Atanu, Francis O. ;
Batiha, Gaber El-Saber .
BIOMEDICINE & PHARMACOTHERAPY, 2021, 143
[7]   Levamisole Therapy in COVID-19 [J].
Al-Kuraishy, Hayder M. ;
Al-Gareeb, Ali, I ;
Alkazmi, Luay ;
Alexiou, Athanasios ;
Batiha, Gaber El-Saber .
VIRAL IMMUNOLOGY, 2021, 34 (10) :722-725
[8]   Role of leukotriene pathway and montelukast in pulmonary and extrapulmonary manifestations of Covid-19: The enigmatic entity [J].
Al-kuraishy, Hayder M. ;
Al-Gareeb, Ali I. ;
Almulaiky, Yaaser Q. ;
Cruz-Martins, Natalia ;
Batiha, Gaber El-Saber .
EUROPEAN JOURNAL OF PHARMACOLOGY, 2021, 904
[9]   The Looming Effects of Estrogen in Covid-19: A Rocky Rollout [J].
Al-kuraishy, Hayder M. ;
Al-Gareeb, Ali I. ;
Faidah, Hani ;
Al-Maiahy, Thabat J. ;
Cruz-Martins, Natalia ;
Batiha, Gaber El-Saber .
FRONTIERS IN NUTRITION, 2021, 8
[10]   Sequential doxycycline and colchicine combination therapy in Covid-19: The salutary effects [J].
Al-kuraishy, Hayder M. ;
Al-Gareeb, Ali, I ;
Qusty, Naeem ;
Cruz-Martins, Natalia ;
Batiha, Gaber El-Saber .
PULMONARY PHARMACOLOGY & THERAPEUTICS, 2021, 67
12345678910