The regulation of drug-metabolizing enzymes and membrane transporters by inflammation: Evidences in inflammatory diseases and age-related disorders

被引：65
|
作者：
Wu, Kuo-Chen [1 ]
Lin, Chun-Jung [1 ]
机构：
[1] Natl Taiwan Univ, Sch Pharm, 33 Linsen South Rd, Taipei 100, Taiwan
来源：
JOURNAL OF FOOD AND DRUG ANALYSIS | 2019年 / 27卷 / 01期
关键词：
Drug-metabolizing enzyme; Inflammation; Membrane transporter; Pharmacokinetics; PREGNANE-X-RECEPTOR; NF-KAPPA-B; CONSTITUTIVE ANDROSTANE RECEPTOR; P-GLYCOPROTEIN EXPRESSION; BLOOD-BRAIN-BARRIER; ADJUVANT-INDUCED ARTHRITIS; MESSENGER-RNA EXPRESSION; MDR1; GENE-EXPRESSION; HEPATIC CYTOCHROME-P450; GLUCOCORTICOID-RECEPTOR;
D O I：
10.1016/j.jfda.2018.11.005
中图分类号：
TS2 [食品工业];
学科分类号：
0832 ;
摘要：
Drug-metabolizing enzymes (DMEs) and membrane transporters play important roles in the absorption, distribution, metabolism, and excretion processes that determine the pharmacokinetics of drugs. Inflammation has been shown to regulate the expression and function of these drug-processing proteins. Given that inflammation is a common feature of many diseases, in this review, the general mechanisms for inflammation-mediated regulation of DMEs and transporters are described. Also, evidences regarding the aberrant expression of these drug-processing proteins in several inflammatory diseases and age-related disorders are provided. Copyright (C) 2018, Food and Drug Administration, Taiwan. Published by Elsevier Taiwan LLC.
引用
收藏
页码：48 / 59
页数：12
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