Synthesis of N-alkoxy-substituted 2H-benzimidazoles

被引：3
|
作者：
Ansari, Nurul H. [1 ]
Soderberg, Bjorn C. G. [1 ]
机构：
[1] West Virginia Univ, C Eugene Bennett Dept Chem, Morgantown, WV 26506 USA
来源：
TETRAHEDRON LETTERS | 2017年 / 58卷 / 50期
基金：
美国国家科学基金会; 美国国家卫生研究院;
关键词：
Cyclization; Benzimidazole; Alkylation; 2-Nitroanilines; Enamine; ONE-POT; BENZIMIDAZOLES; OXIDES;
D O I：
10.1016/j.tetlet.2017.11.007
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Treatment of 2-nitro-N-(2-methyl-l-propen-1-yl)benzenamines with potassium tert-butoxide in tert-butanol followed by the addition of an electrophile affords N-alkoxy-2H-benzimidazoles. Electrophiles including methyl iodide, allylic bromides, propargylic bromides, benzyl bromide, and acetyl chloride gave good to excellent yields of product while 1-iodo-and 2-iodo-butane afforded very low yields. (C) 2017 Elsevier Ltd. All rights reserved.
引用
收藏
页码：4717 / 4720
页数：4
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