Synthesis of N-alkoxy-substituted 2H-benzimidazoles

被引：3

作者：

Ansari, Nurul H. ^{[1
]}

Soderberg, Bjorn C. G. ^{[1
]}

机构：

[1] West Virginia Univ, C Eugene Bennett Dept Chem, Morgantown, WV 26506 USA

来源：

TETRAHEDRON LETTERS | 2017年 / 58卷 / 50期

基金：

美国国家科学基金会; 美国国家卫生研究院;

关键词：

Cyclization; Benzimidazole; Alkylation; 2-Nitroanilines; Enamine; ONE-POT; BENZIMIDAZOLES; OXIDES;

D O I：

10.1016/j.tetlet.2017.11.007

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Treatment of 2-nitro-N-(2-methyl-l-propen-1-yl)benzenamines with potassium tert-butoxide in tert-butanol followed by the addition of an electrophile affords N-alkoxy-2H-benzimidazoles. Electrophiles including methyl iodide, allylic bromides, propargylic bromides, benzyl bromide, and acetyl chloride gave good to excellent yields of product while 1-iodo-and 2-iodo-butane afforded very low yields. (C) 2017 Elsevier Ltd. All rights reserved.

引用

页码：4717 / 4720

页数：4

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